succinate-semialdehyde dehydrogenase

succinate-semialdehyde dehydrogenase
suc·ci·nate-semi·al·de·hyde de·hy·dro·gen·ase (sukґsĭ-nāt sem″e-alґdə-hīd de-hiґdro-jən-ās) [EC 1.2.1.24] an enzyme of the oxidoreductase class that catalyzes the oxidation of γ-hydroxybutyric acid to succinate. The reaction is the final step in the inactivation of γ-aminobutyric acid (GABA); when enzyme activity is deficient, increased levels of GABA and γ-hydroxybutyric acid can be detected in urine, plasma, and cerebrospinal fluid.

Medical dictionary. 2011.

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  • Succinate-semialdehyde dehydrogenase — In enzymology, a succinate semialdehyde dehydrogenase (EC number|1.2.1.24) is an enzyme that catalyzes the chemical reaction:succinate semialdehyde + NAD+ + H2O ightleftharpoons succinate + NADH + 2 H+The 3 substrates of this enzyme are succinate …   Wikipedia

  • Succinate-semialdehyde dehydrogenase (NAD(P)+) — In enzymology, a succinate semialdehyde dehydrogenase [NAD(P)+] (EC number|1.2.1.16) is an enzyme that catalyzes the chemical reaction:succinate semialdehyde + NAD(P)+ + H2O ightleftharpoons succinate + NAD(P)H + 2 H+The 4 substrates of this… …   Wikipedia

  • succinate-semialdehyde dehydrogenase deficiency — suc·ci·nate semi·al·de·hyde de·hy·dro·gen·ase de·fi·cien·cy (sukґsĭ nāt sem″e alґdə hīd de hiґdro jən ās) an autosomal recessive aminoacidopathy caused by mutation in the succinate semialdehyde dehydrogenase… …   Medical dictionary

  • Succinic semialdehyde dehydrogenase deficiency — Infobox Disease Name = PAGENAME Caption = Gamma Hydroxybutyric acid DiseasesDB = 29825 ICD10 = ICD9 = ICDO = OMIM = 271980 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = Succinic semialdehyde dehydrogenase deficiency (SSADHD), also known …   Wikipedia

  • succinate semialdehyde — An intermediate in the catabolism of γ aminobutyrate. s. dehydrogenase an enzyme that catalyzes the reaction of s. and either NAD+ or NADP+ to form succinate and NADH (or NADPH); a deficiency of this …   Medical dictionary

  • 4-hydroxybutyrate dehydrogenase — In enzymology, a 4 hydroxybutyrate dehydrogenase (EC number|1.1.1.61) is an enzyme that catalyzes the chemical reaction:4 hydroxybutanoate + NAD+ ightleftharpoons succinate semialdehyde + NADH + H+The two substrates of this enzyme are therefore 4 …   Wikipedia

  • ALDH5A1 (gene) — Aldehyde dehydrogenase 5 family, member A1 (succinate semialdehyde dehydrogenase), also known as ALDH5A1, is a human gene.cite web | title = Entrez Gene: ALDH5A1 aldehyde dehydrogenase 5 family, member A1 (succinate semialdehyde dehydrogenase)|… …   Wikipedia

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

  • γ-hydroxybutyric acid — (GHB) butyric acid substituted at the γ, or 4, position; it is an intermediate in the metabolism of γ aminobutyric acid (GABA) and with GABA occurs at elevated levels in some body fluids in succinate semialdehyde dehydrogenase… …   Medical dictionary

  • NCS-382 — IUPAC name (2E) (5 hydroxy 5,7,8,9 tetrahydro 6H benzo[a][7]annulen 6 ylidene ethanoic acid …   Wikipedia

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