cisplatin


cisplatin
A chemotherapeutic agent with antitumor activity; c. binds DNA and interferes with DNA synthesis; strongly emetogenic.

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cis·plat·in 'sis-.plat-ən n a platinum-containing antineoplastic drug Cl2H6N2Pt that functions as an alkylating agent, produces crosslinks in DNA between and within strands, and is used esp. as a palliative therapy in testicular and ovarian tumors and in advanced bladder cancer see PLATINOL

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n.
a heavy-metal compound: a cytotoxic drug that impedes cell division by damaging DNA. Administered intravenously, it is important in the treatment of testicular and ovarian tumours. It is highly toxic; side-effects include nausea, vomiting, kidney damage, peripheral neuropathy, and hearing loss. Less toxic analogue of cisplatin are now available (see carboplatin).

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cis·plat·in (sisґplat-in) [USP] cis-diamminedichloroplatinum, a platinum coordination complex capable of producing inter- and intrastrand DNA crosslinks and having a broad spectrum of antitumor activity, used in the treatment of a wide variety of neoplasms, particularly metastatic ovarian and testicular carcinoma and advanced carcinoma of the bladder; administered intravenously. Called also CDDP, cis-DDP, and DDP.

Medical dictionary. 2011.