Clostridium histolyticum collagenase

Clostridium histolyticum collagenase
An enzyme that catalyzes the hydrolysis of collagen, preferentially at peptide bonds on the amino side of a glycylprolyl sequence. SYN: clostridiopeptidase A, collagenase A, collagenase I, microbial collagenase.

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any of several forms of microbial collagenase isolated from Clostridium histolyticum that catalyze the cleavage of collagen into small fragments, cleaving it in the triple helical region N-terminal to glycine residues. The extracellular Zn2+ enzyme degrades the collagen framework of muscles, facilitating the spread of gas gangrene by C. histolyticum.

Medical dictionary. 2011.

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