corepressor


corepressor
A molecule, usually a product of a specific metabolic pathway, that combines with and activates a repressor produced by a regulator gene. The activated repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism negatively regulates enzyme production in repressible enzyme systems.

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co·re·pres·sor .kō-ri-'pres-ər n a small molecule that activates a particular genetic repressor by combining with it

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co·re·pres·sor (ko″re-presґər) a small molecule that combines with a protein aporepressor molecule to form an active substance, which then binds to an operator gene and inhibits the synthesis of an enzyme. The mechanism is a negative control in inducible enzyme systems.

Medical dictionary. 2011.

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  • corepressor — corepressor. См. корепрессор. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Corepressor — In molecular genetics, a corepressor is a substance that inhibits the expression of genes. A corepressor downregulates (or represses) the expression of genes not through direct interaction with a gene promoter (a sequence of DNA adjacent to the… …   Wikipedia

  • Corepressor — Als Corepressor (Korepressor) bezeichnet man in der Molekularbiologie eine Substanz, die die Expression von Genen hemmt. Ein Corepressor vermindert die Expression von Genen nicht durch direkte Interaktion mit dem Promotor (einer DNA Sequenz neben …   Deutsch Wikipedia

  • corepressor — noun Date: 1963 a small molecule that activates a particular genetic repressor by combining with it …   New Collegiate Dictionary

  • corepressor — (ko re pre sor) A small molecule that inhibits the synthesis of a repressible enzyme …   Dictionary of microbiology

  • corepressor — /koh ri pres euhr/, n. Genetics. a molecule that is capable of combining with a specific repressor molecule and activating it, thereby blocking gene transcription. [1960 65; CO + REPRESSOR] * * * …   Universalium

  • corepressor — noun Any substance that reacts with a genetic repressor in order to activate it and decrease gene expression …   Wiktionary

  • corepressor — co·repressor …   English syllables

  • corepressor — ˌkōˌ noun Etymology: co + repressor (herein) : a small molecule that activates a particular genetic repressor by combining with it * * * /koh ri pres euhr/, n. Genetics. a molecule that is capable of combining with a specific repressor molecule… …   Useful english dictionary

  • Corepressor (genetics) — A corepressor is a protein that decreases gene expression by binding to a transcription factor which contains a DNA binding domain. The corepressor is unable to bind DNA by itself. The corepressor can repress transcriptional initiation by… …   Wikipedia