cyclophosphamide


cyclophosphamide
An alkylating agent with antitumor activity and uses similar to those of its parent compound, nitrogen mustard (mechlorethamine hydrochloride); also a suppressor of B-cell activity and antibody formation, used to treat autoimmune diseases.

* * *

cy·clo·phos·pha·mide -'fäs-fə-.mīd n an immunosuppressive and antineoplastic drug C7H15Cl2N2O2P used to treat lymphomas and some leukemias see CYTOXAN

* * *

n.
an alkylating agents used to treat a variety of cancers, often in combination with other cytotoxic drug. It also has immunosuppressant properties and is used in treating conditions, notably rheumatoid arthritis, requiring a reduced immune response. Cyclophosphamide is administered by mouth or by injection; common side-effects are nausea, vomiting, and - particularly at high doses - hair loss. Trade name: Endoxana.

* * *

cy·clo·phos·pha·mide (CPM) (CYC) (si″klo-fosґfə-mīd) [USP] a cytotoxic alkylating agent of the nitrogen mustard group, used as an antineoplastic, often in combination with other agents, for a wide variety of conditions, including Hodgkin disease, lymphosarcoma, acute lymphocytic leukemia, Burkitt lymphoma, carcinoma of the breast, multiple myeloma, chronic lymphocytic leukemia, bronchogenic carcinoma, neuroblastoma, ovarian carcinoma, and carcinoma of the uterine cervix; also used as an immunosuppressive agent to prevent transplant rejection and in the treatment of certain diseases with abnormal immune function. Cyclophosphamide itself is pharmacologically inert; several active metabolites are produced by the microsomal enzyme systems in the liver.

Medical dictionary. 2011.

Look at other dictionaries:

  • Cyclophosphamide — Systematic (IUPAC) name …   Wikipedia

  • Cyclophosphamide — Énantiomère S du cyclophosphamide (à gauche) et R cyclophosphamide (à droite) Général …   Wikipédia en Français

  • cyclophosphamide — cyclophosphamide. См. циклофосфамид. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • cyclophosphamide — [sī΄klō fäs′fə mīd΄; sī΄klō fäs fam′īd΄, sī΄klō fäs fam′id΄] n. [ CYCLO + PHOSPH(ORIC) + AMIDE] a white, crystalline compound, C7H15Cl2N2O2P, used in treating certain malignancies, esp. lymphomas …   English World dictionary

  • cyclophosphamide — n. an alkylating agent used to treat a variety of cancers, often in combination with other cytotoxic drugs. It also has immunosuppressant properties and is used in treating conditions, notably rheumatoid arthritis, requiring a reduced immune… …   The new mediacal dictionary

  • cyclophosphamide — noun Date: 1960 an immunosuppressive and antineoplastic agent C7H15Cl2N2O2P used especially in the treatment of lymphomas and some leukemias …   New Collegiate Dictionary

  • cyclophosphamide — An alkylating agent and important immunosuppressant. Acts by alkylating SH and NH2 groups especially the N7 of guanine …   Dictionary of molecular biology

  • cyclophosphamide — /suy kleuh fos feuh muyd , mid, sik leuh /, n. Pharm. a synthetic, crystalline, toxic substance, C7H15Cl2N2O2P, related to nitrogen mustard, used in the treatment of Hodgkin s disease, lymphoma, and certain leukemias. Abbr.: CYC [1955 60; CYCLO + …   Universalium

  • cyclophosphamide — noun An immunosuppressive, antineoplastic drug used in the treatment of Hodgkins disease and certain other forms of cancer …   Wiktionary

  • cyclophosphamide — [ˌsʌɪklə(ʊ) fɒsfəmʌɪd] noun Medicine a synthetic drug used in treating leukaemia and lymphoma and as an immunosuppressive agent …   English new terms dictionary


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.