- - antibody-dependent cell-mediated c. (ADCC) a form of cell-mediated c. that functions by binding of the FC region of IgG antibodies to Fc receptors on leukocytes. The FAB region of the antibody binds to the target cell. Killing of the target cell may be through various modalities, e.g., perforin, reactive oxygen intermediates, cytokines.- lymphocyte-mediated c. the toxic or lytic activity of lymphocytes, which may or may not be mediated by antibodies. Cytotoxic T lymphocytes may cause lysis of cells by production of cytolytic proteins such as perforin. B cells may cause lysis of cells by antibody-complement binding to a target cell. Natural killer cells are cytotoxic without prior sensitization. SEE ALSO: antibody-dependent cell-mediated c..
* * *cy·to·tox·ic·i·ty (si″to-tok-sisґĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action; used particularly in referring to the lysis of cells by immune phenomena and to antineoplastic drugs that selectively kill dividing cells. cytotoxic adj
Medical dictionary. 2011.
Look at other dictionaries:
Cytotoxicity — is the quality of being toxic to cells. Examples of toxic agents are a chemical substance, an immune cell or some types of venom (e.g. from the puff adder or brown recluse spider). Contents 1 Cell physiology 2 Measuring cytotoxicity … Wikipedia
cytotoxicity — noun see cytotoxic … New Collegiate Dictionary
cytotoxicity — /suy toh tok sis i tee/, n. cell destruction caused by a cytotoxic substance. [CYTOTOXIC + ITY] * * * … Universalium
cytotoxicity — noun the state of being toxic to cells See Also: cytotoxic … Wiktionary
cytotoxicity — n. poisoning of cells … English contemporary dictionary
cytotoxicity — cy·to·toxicity … English syllables
cytotoxicity — cy•to•tox•ic•i•ty [[t]ˌsaɪ toʊ tɒkˈsɪs ɪ ti[/t]] n. pat pha cell destruction caused by a cytotoxin • Etymology: 1955–60 … From formal English to slang
cytotoxicity — Poisoning of the cell … Glossary of Biotechnology
cytotoxicity — noun the degree to which something is toxic to living cells • Hypernyms: ↑toxicity * * * noun see cytotoxic * * * /suy toh tok sis i tee/, n. cell destruction caused by a cytotoxic substance. [CYTOTOXIC + ITY] * * * cytotoxicˈity noun • • • … Useful english dictionary
Antibody-dependent cell-mediated cytotoxicity — An immune response in which antibody, by coating target cells, makes them vulnerable to attack by immune cells. Antibody dependent cell mediated cytotoxicity is commonly (and blissfully) abbreviated ADCC. * * * (ADCC), antibody dependent cellular … Medical dictionary