Cornelia de Lange syndrome
A relatively common birth defect syndrome with multiple malformations and mental retardation of unknown origin that is recognized by the presence of: Prenatal and postnatal growth retardation; Delayed development and mental retardation; Abnormally small head (microcephaly); Hair low on the nape of the neck; Characteristic facial appearance with Low-set ears, Hair well down onto the forehead, Bushy eyebrows, Eyebrows that meet in the middle (synophrys), Unusually long eyelashes, Depressed bridge of the nose, Uptilted tip of the nose, Forward-directed nostrils, Protuberance of the upper jaw (maxillary prognathism), "Carp-shaped" mouth, and Small, widely spaced teeth; and Upper limb anomalies with flat spadelike hands with a "simian" (single transverse) palmar crease and short tapering fingers. The great majority of children with de Lange syndrome have no known family history of the disorder. There are, however, some reports of familial cases. These reports suggest autosomal dominant transmission with a mildly affected parent having a more seriously affected child. The chance is from 2 to 5% that a child whose sib has de Lange syndrome will also have the syndrome. The syndrome is named for a Dutch physician, de Lange (whose first name was Cornelia). She was professor of pediatrics in Amsterdam. In 1933, Dr. de Lange reported 2 infant girls with mental deficiency and other features now associated with the syndrome. The syndrome is also called the Brachmann-de Lange syndrome, thanks to Dr. John Opitz who has recounted that: "In the fall of 1963...the former head of the...Libraries, came to ask my advice on what to do with a series of volumes of the Jahrbuch fur Kinderheilkunde, which had been damaged...by a burst water pipe. In particular, she was upset by volume 84, dated 1916, the pages of which were completely glued together except for one place, the article beginning on p. 225. I was startled to find out that here was an article on the Cornelia de Lange syndrome written 17 years before de Lange's first paper of 1933. The author, Dr. W. Brachmann, whose subsequent fate is unknown to me, was then a young physician in training, who apologized that his study of this remarkable case was interrupted by sudden orders to report for active duty (in the German Army)."

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de Lange s.

Medical dictionary. 2011.

Look at other dictionaries:

  • Cornelia de Lange Syndrome — Classification and external resources ICD 10 Q87.1 (ILDS Q87.170) ICD 9 759.89 …   Wikipedia

  • Syndrome de cornelia de lange — Autre nom Syndrome de Brachmann de Lange Référence MIM …   Wikipédia en Français

  • Syndrome de Cornelia de Lange — Référence MIM 122470 300590 Transmission Dominante Liée au chromosome X Chromosome 5p13.1 Xp11.22 p11.21 Gène …   Wikipédia en Français

  • Syndrome, Cornelia de Lange — A relatively common birth defect syndrome with multiple malformations and mental retardation of unknown origin that is recognized by the presence of: Prenatal and postnatal growth retardation; Delayed development and mental retardation;… …   Medical dictionary

  • Brachmann-de Lange syndrome — A relatively common birth defect syndrome, also known as the de Lange syndrome, with multiple malformations and mental retardation of unknown origin. The syndrome is recognized by the presence of: Prenatal and postnatal growth retardation;… …   Medical dictionary

  • Síndrome de Cornelia de Lange — Clasificación y recursos externos CIE 10 Q87.1 CIE 9 054 OMIM …   Wikipedia Español

  • de Lange syndrome — A relatively common syndrome with multiple congenital malformations (birth defects) and mental retardation of unknown origin that is recognized by the presence of: Prenatal and postnatal growth retardation; Delayed development and mental… …   Medical dictionary

  • síndrome de Cornelia de Lange — Eng. Cornelia de Lange s syndrome Enanismo congénito no armónico que a nivel ocular presenta tricomegalia de cejas y pestañas, sinofridia, hendidura palpebral antimongoloide, blefarofimosis, microftalmos, exoftalmos, nistagmo lateral, exotropía… …   Diccionario de oftalmología

  • Syndrome, Brachmann-de Lange — A relatively common birth defect syndrome, also known as the de Lange syndrome, with multiple malformations and mental retardation of unknown origin. The syndrome is recognized by the presence of: Prenatal and postnatal growth retardation;… …   Medical dictionary

  • Syndrome, de Lange — A relatively common syndrome with multiple congenital malformations (birth defects) and mental retardation of unknown origin that is recognized by the presence of: Prenatal and postnatal growth retardation; Delayed development and mental… …   Medical dictionary

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