doxorubicin


doxorubicin
An antineoplastic antibiotic isolated from Streptomyces peucetius; also used in cytogenetics to produce Q-type chromosome bands. SYN: adriamycin.

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doxo·ru·bi·cin .däk-sə-'rü-bə-sən n an anthracycline antibiotic with broad antineoplastic activity that is obtained from a bacterium of the genus Streptomyces (S. peucetius) and is administered in the form of its hydrochloride C27H29NO11·HCl see ADRIAMYCIN

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n.
an anthracycline anti-biotic isolated from Streptomyces peucetius caesius and used mainly in the treatment of leukaemia and various other forms of cancer. Doxorubicin acts by interfering with the production of DNA and RNA (see also cytotoxic drug). It is administered by injection or infusion and can be given as a lipid formulation (Caelyx; see liposome); side-effects include bone marrow depression, baldness, gastrointestinal disturbances, and heart damage.

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doxo·ru·bi·cin (dok″so-rooґbĭ-sin) an anthracycline (q.v.) antibiotic produced by Streptomyces peucetius var. caesius having one of the widest spectrums of antitumor activity of any antineoplastic agent.

Medical dictionary. 2011.

Look at other dictionaries:

  • Doxorubicin — Systematic (IUPAC) name (7S,9S) 7 [(2R,4S,5S,6S) 4 amino 5 hydroxy 6 methyloxan 2 yl]oxy 6,9,11 trihydroxy 9 (2 hydroxyacetyl) 4 methoxy 8,10 dihydro 7H tetracene 5,12 dione Clinical data …   Wikipedia

  • Doxorubicin — Strukturformel Allgemeines Freiname Doxorubicin Andere Namen …   Deutsch Wikipedia

  • doxorubicin — A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces peucetius. It damages DNA (the molecules inside cells that carry genetic… …   English dictionary of cancer terms

  • doxorubicin — n. an anthracycline antibiotic isolated from Streptomyces peucetius caesius and used mainly in the treatment of leukaemia and various other forms of cancer. Doxorubicin acts by interfering with the production of DNA and RNA (see also cytotoxic… …   The new mediacal dictionary

  • doxorubicin — noun Etymology: deoxy + orubicin (as in daunorubicin) Date: 1971 an antibiotic with broad antineoplastic activity that is obtained from a bacterium (Streptomyces peucetius) and is administered in the form of its hydrochloride C27H29NO11•HCl …   New Collegiate Dictionary

  • doxorubicin — Cytotoxic antibiotic from Streptomyces peucetius. Blocks topoisomerase and reverse transcriptase by intercalating into the DNA. Has been used in clinical oncology …   Dictionary of molecular biology

  • doxorubicin — /dok seuh rooh beuh sin/, n. Pharm. a cytotoxic antibiotic, C27H29NO11, derived from a variety of the bacterium Streptomyces peucetius and used in the treatment of sarcoma, malignant lymphoma, acute leukemia, and other cancers. [D(E)OX(Y) + O + L …   Universalium

  • doxorubicin — noun A particular drug used in chemotherapy. Syn: adriamycin, hydroxydaunorubicin …   Wiktionary

  • Doxorubicin — Do|xo|ru|bi|cin [Kunstw. zu lat. rubicundus = rötlich (wegen der Kristallfarbe)], das; s: ↑ Anthracyclin …   Universal-Lexikon

  • doxorubicin — [ˌdɒksəʊ ru:bɪsɪn] noun Medicine a bacterial antibiotic used to treat leukaemia and other forms of cancer. Origin 1970s: from deoxy (in the sense that has lost oxygen ) + L. rubus red + mycin …   English new terms dictionary


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