endotoxin
1. A bacterial toxin not freely liberated into the surrounding medium, in contrast to exotoxin. 2. The complex phospholipid-polysaccharide macromolecules that form an integral part of the cell wall of a variety of relatively avirulent as well as virulent strains of Gram-negative bacteria. The toxins are relatively heat-stable, are less potent than most exotoxins, are less specific, and do not form toxoids; on injection, they may cause a state of shock and, in smaller doses, fever and leukopenia followed by leukocytosis; they have the capacity of eliciting the Shwartzman and the Sanarelli-Shwartzman phenomena. SYN: intracellular toxin.

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en·do·tox·in .en-dō-'täk-sən n a toxin of internal origin specif a poisonous substance present in bacteria (as the causative agent of typhoid fever) but separable from the cell body only on its disintegration compare EXOTOXIN
en·do·tox·ic -sik adj

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n.
a poison generally harmful to all body tissues, contained within certain Gram-negative bacteria and released only when the bacterial cell is broken down or dies and disintegrates. Compare exotoxin.

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en·do·tox·in (enґdo-tok″sin) [endo- + toxin] a heat-stable toxin associated with the outer membranes of certain gram-negative bacteria, including the brucellae, the enterobacteria, neisseriae, and vibrios. Endotoxins are not secreted but are released only when the cells are disrupted; they are less potent and less specific than the exotoxins; and they do not form toxoids. They are composed of complex lipopolysaccharide molecules, of which the polysaccharide unit (somatic O antigen) is responsible for antigenicity, occurring in hundreds of variations, and the phospholipid moiety (lipid A) is the source of toxicity. When injected in large quantities the endotoxins produce hemorrhagic shock and severe diarrhea; smaller amounts cause fever, altered resistance to bacterial infection, leukopenia followed by leukocytosis, and numerous other biologic effects. Called also bacterial pyrogen. See also toxin.

Medical dictionary. 2011.

Look at other dictionaries:

  • endotoxin — endotoxin. См. эндотоксин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • endotoxin — [en΄dō täks′in] n. [ ENDO + TOXIN] the polysaccharide that is combined with a lipid and released from the cell walls of Gram negative bacteria, producing toxic effects causing fever, shock, etc. in many animals …   English World dictionary

  • Endotoxin — Endotoxins (not to be confused with enterotoxin) are potentially toxic, natural compounds found inside pathogens such as bacteria. Classically, an endotoxin is a toxin which, unlike an exotoxin , is not secreted in soluble form by live bacteria,… …   Wikipedia

  • endotoxin — Heat stable polysaccharide like toxin bound to a bacterial cell. The term is used more specifically to refer to lipopolysaccharide (LPS) of the outer membrane of Gram negative bacteria. There are three parts to the molecule, the Lipid A (six… …   Dictionary of molecular biology

  • Endotoxin — endotoksinas statusas T sritis ekologija ir aplinkotyra apibrėžtis Toksinas, kuris į aplinką patenka tik iš suirusių bakterijų. atitikmenys: angl. endotoxin vok. Endotoxin, n rus. эндотоксин, m …   Ekologijos terminų aiškinamasis žodynas

  • endotoxin — endotoksinas statusas T sritis ekologija ir aplinkotyra apibrėžtis Toksinas, kuris į aplinką patenka tik iš suirusių bakterijų. atitikmenys: angl. endotoxin vok. Endotoxin, n rus. эндотоксин, m …   Ekologijos terminų aiškinamasis žodynas

  • Endotoxin — Endotoxine sind eine Klasse biochemischer Stoffe. Sie sind Zerfallsprodukte von Bakterien, die im Menschen zahlreiche physiologische Reaktionen auslösen können. Inhaltsverzeichnis 1 Definition 2 Wortherkunft 3 Wirkungen 4 Nac …   Deutsch Wikipedia

  • endotoxin — endotoxic, adj. /en doh tok sin/, n. Biochem. the toxic protoplasm liberated when a microorganism dies and disintegrates, as in Eberthella typhi, the causative agent of typhoid fever. Cf. exotoxin. [1900 05; ENDO + TOXIN] * * * ▪ bacterial toxin… …   Universalium

  • endotoxin — endotoksinas statusas T sritis chemija apibrėžtis Toksinas, kuris į aplinką patenka tik iš žuvusių ir suirusių bakterijų. atitikmenys: angl. endotoxin rus. эндотоксин …   Chemijos terminų aiškinamasis žodynas

  • endotoxin — noun Etymology: International Scientific Vocabulary Date: 1904 a toxic heat stable lipopolysaccharide substance present in the outer membrane of gram negative bacteria that is released from the cell upon lysis • endotoxic adjective …   New Collegiate Dictionary

  • endotoxin — n. [Gr. endon, within; toxikon, poison] A substance produced by microorganisms which is confined within the microbial cell; see exotoxin …   Dictionary of invertebrate zoology

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