floxuridine


floxuridine
The deoxynucleoside of fluorouracil; an antineoplastic agent. Fluorouracil is metabolized to f. and this, in turn, to 5-fluoro-2′-deoxyuridine 5′-monophosphate. The latter agent inhibits thymidylic synthetase; uridine phosphatase is also inhibited.

* * *

flox·uri·dine (floks-ūrґĭ-dēn) [USP] a fluoropyrimidine that is metabolically activated to the monophosphate nucleotide (F-dUMP), the metabolite of 5-fluorouracil (q.v.) that blocks DNA synthesis; FUDR is also metabolized to 5-fluorouracil; it is used as an antineoplastic by intra-arterial administration for treatment of liver metastases from gastrointestinal malignancies.

Medical dictionary. 2011.

Look at other dictionaries:

  • Floxuridine — drugbox IUPAC name = 5 Fluoro 1 [4 hydroxy 5 (hydroxymethyl)tetrahydrofuran 2 yl] 1H pyrimidine 2,4 dione CAS number = 50 91 9 ATC prefix = ATC suffix = ATC supplemental = PubChem = 5790 DrugBank = APRD00692 C=9 | H=11 | F=1 | N=2 | O=5 molecular …   Wikipedia

  • floxuridine — noun A particular drug used in chemotherapy …   Wiktionary

  • floxuridine — A drug used in the treatment of cancer. It is a type of antimetabolite …   English dictionary of cancer terms

  • floxuridine — noun antineoplastic drug used to treat some cancers; can cause loss of hair • Hypernyms: ↑antineoplastic, ↑antineoplastic drug, ↑cancer drug …   Useful english dictionary

  • FUDR — Abbreviation for fluorodeoxyuridine. See floxuridine. * * * fluorodeoxyuridine * * * 1. abbreviation for floxuridine (5 fluorouracil deoxyribonucleoside). 2. trademark for a preparation of floxuridine …   Medical dictionary

  • Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia

  • Paclitaxel — Systematic (IUPAC) name (2α,4α,5β,7β,10β,13α) 4,10 bis(acetyloxy) …   Wikipedia

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia

  • Everolimus — Systematic (IUPAC) name dihydroxy 12 [(2R) 1 [(1S,3R,4R) 4 (2 hydroxyethoxy) 3 methoxycyclohexyl]propan 2 yl] 19,30 dimethoxy 15,17,21,23,29,35 hexamethyl 11,36 dioxa 4 azatricyclo[30.3.1.04,9]hexatriaconta 16,24,26,28 tetraene 2,3,10,14,20… …   Wikipedia

  • Tretinoin — Systematic (IUPAC) name retinoic acid …   Wikipedia