gelsolin


gelsolin
An actin-binding protein; a Ca2+-triggered actin-filament-severing protein; hence, it has roles in locomotion, secretion, and endocytosis.

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gel·sol·in (jel-solґin) any of a family of actin-binding proteins that sever and cap actin filaments at high calcium concentrations, thus controlling the length of actin filaments and lowering the viscosity of cytoplasm in processes such the formation of filopodia. They also bind to phosphatidylinositol bisphosphate, linking actin organization and signal transduction. See also profilin.

Medical dictionary. 2011.

Look at other dictionaries:

  • Gelsolin — is an actin binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.cite journal… …   Wikipedia

  • gelsolin — Actin binding protein (90 kD) that nucleates actin polymerization, but at high calcium ion concentrations (10 6 M) causes severing of filaments …   Dictionary of molecular biology

  • gelsolin — gel·sol·in (jĕl sŏlʹĭn) n. A calcium dependent actin binding protein that modulates actin filament length and gelation and thus influences the structure of the cytoskeleton and plays a key role in cellular motility and differentiation.  … …   Universalium

  • gelsolin — noun An actin binding protein that is a key regulator of actin filament assembly and disassembly …   Wiktionary

  • ACTG1 — Actin, gamma 1 PDB rendering based on 1atn …   Wikipedia

  • Actin, alpha 1 — Actin, alpha 1, skeletal muscle PDB rendering based on 1atn …   Wikipedia

  • CAPG — Capping protein (actin filament), gelsolin like, also known as CAPG, is a human gene.cite web | title = Entrez Gene: CAPG capping protein (actin filament), gelsolin like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Intracellular calcium-sensing proteins — are proteins that act in the second messenger system. Examples include: calmodulin calnexin calreticulin gelsolin External links MeSH Intracellular+Calcium Sensing+Proteins …   Wikipedia

  • FLII — Flightless I homolog (Drosophila), also known as FLII, is a human gene.cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2314| accessdate …   Wikipedia

  • Destrin — (actin binding protein) Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.[1] Identifiers …   Wikipedia


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