homogentisate 1,2-dioxygenase

homogentisate 1,2-dioxygenase
An iron-containing enzyme that catalyzes the oxidative cleavage of the benzene ring in homogentisic acid by O2, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria. SYN: homogentisic acid oxidase.

Medical dictionary. 2011.

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  • Homogentisate 1,2-dioxygenase — protein Name=homogentisate 1,2 dioxygenase (homogentisate oxidase) caption= 3D rendering of Homogentisate Dioxygenase with active site amino acid residues and Iron atom colored. Histidine is the tan color, Glutamate the red color, and Iron is the …   Wikipedia

  • homogentisate 12-dioxygenase — ho·mo·gen·tis·ate 1,2 di·oxy·gen·ase (ho″mo jən tisґāt di okґsə jən ās) [EC 1.13.11.5] an enzyme of the oxidoreductase class that catalyzes the oxidation of homogentisate to form 4 methylacetoacetate as a step in… …   Medical dictionary

  • Cysteine dioxygenase — cysteine dioxygenase, type I Identifiers Symbol CDO1 Entrez 1036 HUGO …   Wikipedia

  • 4-Hydroxyphenylpyruvate dioxygenase — Protein Name=4 hydroxyphenylpyruvate dioxygenase Symbol=HPD AltSymbols=PPD; HGNCid=5147 Chromosome=12 Arm=q Band=24 qter LocusSupplementaryData= ECnumber=1.13.11.27 OMIM=609695 EntrezGene=3242 RefSeq=NM 002150 UniProt=P327544… …   Wikipedia

  • 4-hydroxyphenylpyruvate dioxygenase — 4 hy·droxy·phen·yl·py·ru·vate di·oxy·gen·ase (hi drok″se fen″əl piґroo vāt di okґsə jən ās) [EC 1.13.11.27] an enzyme of the oxidoreductase class that catalyzes the oxidation of p hydroxyphenylpyruvate to… …   Medical dictionary

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

  • Alkaptonuria — Infobox Disease Name = PAGENAME Caption = Homogentisic acid Width = 180 DiseasesDB = 409 ICD10 = ICD10|E|70|2|e|70 ICD9 = ICD9|270.2 ICDO = OMIM = 203500 MedlinePlus = eMedicineSubj = ped eMedicineTopic = 64 MeshID = D000474 Alkaptonuria (black… …   Wikipedia

  • Oxygenase — An oxygenase is any enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O2 (as in air) to it. The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14. Oxygenases were discovered in 1955… …   Wikipedia

  • Oxidoreductase — In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the reductant, also called the hydrogen or electron donor) to another (the oxidant, also called the hydrogen or electron acceptor). This… …   Wikipedia

  • Tyrosine — NatOrganicBox name=( S ) 2 Amino 3 (4 hydroxyphenyl) propanoic acid PubChem = 1153 CAS = 60 18 4 SMILES = N [C@@H] (Cc1ccc(O)cc1)C(O)=O C=9 | H=11 | N=1 | O=3 mass=181.19 g/molTyrosine (abbreviated as Tyr or Y) [cite web | author=IUPAC IUBMB… …   Wikipedia

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