homogentisic acid


homogentisic acid
Glycosuric acid; (2,5-dihydroxyphenyl)acetic acid; an intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in individuals having alcaptonuria. SYN: alcapton, alkapton.
- h. oxidase SYN: homogentisate 1,2-dioxygenase.

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ho·mo·gen·tis·ic acid .hō-mō-.jen-'tiz-ik, .häm-ō- n a crystalline acid C8H8O4 formed as an intermediate in the metabolism of phenylalanine and tyrosine and found esp. in the urine of those affected with alkaptonuria

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a product formed during the metabolism of the amino acids phenylalanine and tyrosine. In normal individuals homogentisic acid is oxidized by the enzyme homogentisic acid oxidase. In rare cases this enzyme is lacking and a condition known as alcaptonuria, in which large amounts of homogentisic acid are excreted in the urine, results.

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ho·mo·gen·tis·ic ac·id (ho″mo-jen-tisґik) an aromatic hydrocarbon formed as an intermediate in the catabolism of tyrosine and phenylalanine. It is accumulated abnormally and excreted in the urine in alkaptonuria.

Medical dictionary. 2011.

Look at other dictionaries:

  • Homogentisic acid — IUPAC name (2,5 Dihydroxyphenyl)acetic acid …   Wikipedia

  • homogentisic acid — homogentisic acid. См. гомогентизиновая кислота. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • homogentisic acid — a product formed during the metabolism of the amino acids phenylalanine and tyrosine. In normal individuals homogentisic acid is oxidized by the enzyme homogentisic acid oxidase. In rare cases this enzyme is lacking and a condition known as… …   The new mediacal dictionary

  • homogentisic acid — homogentizo rūgštis statusas T sritis chemija formulė (HO)₂C₆H₃CH₂COOH atitikmenys: angl. homogentisic acid rus. гомогентизиновая кислота ryšiai: sinonimas – 2,5 dihidroksifeniletano rūgštis …   Chemijos terminų aiškinamasis žodynas

  • homogentisic acid — acid found in the blood and urine of people suffering from alkaptonuria …   English contemporary dictionary

  • homogentisic acid — noun an acid formed as an intermediate product of the metabolism of tyrosine and phenylalanine • Syn: ↑alkapton, ↑alcapton • Hypernyms: ↑acid * * * pronunc at homo +|jen|tizik noun Etymology …   Useful english dictionary

  • homogentisic acid — noun 2,5 dihydroxyphenylacetic acid. Syn: alcapton, alkapton, melanic acid …   Wiktionary

  • homogentisic acid — /hoh meuh jen tis ik, tiz , hoh / an intermediate compound in the metabolism of tyrosine and of phenylalanine, found in excess in the blood and urine of persons affected with alkaptonuria. Also called alkapton. [1890 95; HOMO + GENTISIC ACID] * * …   Universalium

  • homogentisic acid oxidase — ho·mo·gen·tis·ic ac·id ox·i·dase (ho″mo jen tisґik asґid okґsĭ dās) homogentisate 1,2 dioxygenase …   Medical dictionary

  • homogentisic acid oxidase deficiency — ho·mo·gen·tis·ic ac·id ox·i·dase de·fi·cien·cy (ho″mo jen tisґik asґid okґsĭ dās) alkaptonuria …   Medical dictionary