isoenzyme

isoenzyme
One of a group of enzymes that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation; e.g., lactate dehydrogenase, a tetramer composed of varying amounts of α and β subunits ( i.e., 4α, 3α + 1β, 2α + 2β, 1α + 3β, and 4β). SYN: isozyme.
- creatine kinase isoenzymes the isoenzymes of creatine kinase. Creatine kinase is a dimer with M (muscle) and/or B (brain) subunits; it exists in three i. forms: CK-MM, the predominant form, found primarily in skeletal muscle; CK-MB, found in cardiac muscle, tongue, diaphragm, and in small amounts in skeletal muscle; and CK-BB found in the brain, smooth muscle, thyroid, lungs, and prostate. Elevations detected by electrophoresis or other methodologies can be used to help in the differential diagnosis of a variety of disease states, with CK-MB elevations as an important marker following myocardial infarctions, elevations in CK-MM an indicator of muscle disease, and increases in CK-BB an occasional finding following brain infarcts, bowel infarcts, or in the presence of certain malignancies.

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iso·en·zyme -'en-.zīm n any of two or more chemically distinct but functionally similar enzymes called also isozyme
iso·en·zy·mat·ic 'ī-sō-.en-zə-'mat-ik, -zī- adj
iso·en·zy·mic -en-'zī-mik adj

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n.
a physically distinct form of a given enzyme. Isoenzymes catalyse the same type of reaction but have slight physical and immuno-logical differences. Isoenzymes of dehydrogenases, oxidases, transaminases, phosphatases, and proteolytic enzymes are known to exist.

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iso·en·zyme (i″so-enґzīm) isozyme.

Medical dictionary. 2011.

См. также в других словарях:

  • isoenzyme — ● isoenzyme ou isozyme nom féminin ou masculin Chacune des différentes formes sous lesquelles peut exister une enzyme …   Encyclopédie Universelle

  • isoenzyme — [ī΄sō en′zīm] n. an enzyme reacting the same as another enzyme but having a slightly different composition; isozyme …   English World dictionary

  • Isoenzyme — Les isoenzymes (ou isozymes) sont des enzymes présentant une séquence d acides aminés différente d une autre enzyme mais catalysant la même réaction chimique. En médecine clinique, « isozyme » a un sens plus restreint en se limitant à l …   Wikipédia en Français

  • Isoenzyme — Iso|enzyme,   Isozyme, in einem Organismus vorkommende Enzyme mit gleicher Wirkung, aber genetisch unterschiedlich festgelegter Proteinstruktur, meist aus verschiedenen Organen stammend. Die ungleiche Verteilung der Isoenzyme im Organismus führt… …   Universal-Lexikon

  • isoenzyme — noun Date: 1960 any of two or more chemically distinct but functionally similar enzymes • isoenzymatic adjective • isoenzymic adjective …   New Collegiate Dictionary

  • isoenzyme — n. [Gr. isos, equal; en, in; zyme, yeast] An enzyme differing in polymorphic states and isoelectric point, but having the same function; an isozyme …   Dictionary of invertebrate zoology

  • isoenzyme — /uy soh en zuym/, n. Biochem. isozyme. [1955 60; ISO + ENZYME] * * * …   Universalium

  • isoenzyme — noun Any of a group of enzymes that catalyze the same reaction but have different structures and physical, biochemical and immunological properties …   Wiktionary

  • isoenzyme — noun Biochemistry each of two or more enzymes with identical function but different structure …   English new terms dictionary

  • isoenzyme — iso·enzyme …   English syllables


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