lipoic acid

lipoic acid
Functions as the amide (lipoamide) in the disulfide (–S–S–) form in the transfer of “active aldehyde” (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form ( i.e., dihydrolipoic acid) in the process; present in yeast and liver extracts, and may be useful in the treatment of mushroom poisoning. L. is also an essential component of other α-keto acid dehydrogenase complexes. SYN: acetate replacement factor, ovoprotogen, protogen, protogen A, pyruvate oxidation factor, thioctic acid.

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li·po·ic acid li-.pō-ik-, lī- n any of several microbial growth factors esp a crystalline compound C8H14O2S2 that is essential for the oxidation of alpha-keto acids (as pyruvic acid) in metabolism called also protogen

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a sulphur-containing compound that can be readily interconverted to and from its reduced form, dihydrolipoic acid. Lipoic acid functions in carbohydrate metabolism as one of the coenzyme in the oxidative decarboxylation of pyruvate and other a-keto acids.

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lipo·ic ac·id (lip-oґik) a necessary cofactor of the pyruvate dehydrogenase, branched-chain α-keto acid dehydrogenase, and α-ketoglutarate dehydrogenase complexes; it contains a reactive disulfide group that can bind and transfer reaction intermediates. In the enzyme complexes it occurs as lipoamide (q.v.). It is used as a dietary supplement for its antioxidant properties. Called also α-lipoic acid.

Medical dictionary. 2011.

См. также в других словарях:

  • Lipoic acid — Chembox new ImageFile = Lipoic acid 2D skeletal.png ImageSize = ImageFile1 = Lipoic acid 3D vdW.png IUPACName = 5 [(3 R ) dithiolan 3 yl] pentanoic acid OtherNames = α lipoic acid (alpha lipoic acid), thioctic acid, 6,8 dithiooctanoic acid… …   Wikipedia

  • lipoic acid — a sulphur containing compound that can be readily interconverted to and from its reduced form, dihydrolipoic acid. Lipoic acid functions in carbohydrate metabolism as one of the coenzymes in the oxidative decarboxylation of pyruvate and other α… …   The new mediacal dictionary

  • lipoic acid — lipo rūgštis statusas T sritis chemija formulė CH₃C₃H₅S₂(CH₂)₄COOH atitikmenys: angl. lipoic acid; vitamin N rus. витамин N; липоевая кислота ryšiai: sinonimas – vitaminas N sinonimas – (+) 5 [3 (1,2 ditiolanil)]pentano rūgštis …   Chemijos terminų aiškinamasis žodynas

  • lipoic acid — lə̇ˈpōik noun Etymology: lip + ic : any of several microbial growth factors occurring especially in yeast and liver; specifically : the crystalline alpha variety C7H13S2COOH that together with cocarboxylase and other factors is essential for the… …   Useful english dictionary

  • lipoic acid — (= thioctic acid; 1,2 dithiolane 3 valeric acid) Regarded as a coenzyme in the oxoglutarate dehydrogenase complex of the tricarboxylic acid cycle. Involved generally in oxidative decarboxylations of a keto acids. A growth factor for some… …   Dictionary of molecular biology

  • lipoic acid — noun Etymology: lip , lipo Date: circa 1951 any of several microbial growth factors; especially a fatty acid C8H14O2S2 that is essential for the oxidation of alpha keto acids (as pyruvic acid) in metabolism …   New Collegiate Dictionary

  • lipoic acid — noun A chemical compound, IUPAC name 5 [(3R) dithiolan 3 yl]pentanoic acid, one enantiomer of which is an essential cofactor for many enzyme complexes …   Wiktionary

  • lipoic acid — valeric acid, compound that functions as a growth factor in some organisms and as a treatment for liver disease and mushroom poisoning, type of coenzyme …   English contemporary dictionary

  • alpha-lipoic acid — A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha lipoic acid is made by the… …   English dictionary of cancer terms

  • Кислота Липоевая (Lipoic Acid) — соединение, в состав которого входит сера; легко может преобразовываться в свою низшую форму дигидролипоевую кислоту (dihydrolipoic acid) и обратно в липоевую кислоту. Липоевая кислота является одним из коферментов в процессе окислительного… …   Медицинские термины


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