Fragile X chromosome
An X chromosome with a heritable fragile site associated with a frequent form of mental retardation — the fragile X syndrome. The fragile X chromosome was first sighted by Dr. Herbert A. Lubs in 1969 who termed it the "marker X.". The fragile X is also called FRAXA. It was the first fragile site found on the X chromosome. The fragile X chromosome is due to a trinucleotide repeat sequence (a recurring motif of 3 bases) in the DNA at that spot.

Medical dictionary. 2011.

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  • Chromosome, marker — An abnormal chromosome that is distinctive in appearance but not fully identified. A marker chromosome is not a marker of a specific disease. It is a marker chromosome merely in the sense that it can be distinguished under the microscope from all …   Medical dictionary

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