neuraminidase

neuraminidase
SYN: sialidase.

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neur·amin·i·dase .n(y)u̇r-ə-'min-ə-.dās, -.dāz n a hydrolytic enzyme that occurs on the surface of the pneumococcus, the orthomyxoviruses, and some paramyxoviruses and that cleaves terminal acetylated neuraminic acids from sugar residues (as in glycoproteins and mucoproteins)

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neu·ra·min·i·dase (noor″ə-minґĭ-dās) an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Cytosolic, plasma membrane, and lysosomal forms of the enzyme exist; deficiency of the latter, an autosomal recessive trait, causes sialidosis; enzyme activity is also lacking in galactosialidosis. Viral neuraminidase found on the surface of influenza viruses enables viral release from the host cell. In EC nomenclature, called exo-α-sialidase. Called also sialidase.

Medical dictionary. 2011.

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  • Neuraminidase — Bezeichner Gen Namen …   Deutsch Wikipedia

  • Neuraminidase — Neuraminic acid Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The most commonly known… …   Wikipedia

  • Neuraminidase — Pour les articles homonymes, voir N1, N2, N3, N4, N5, N6, N7, N8 et N9 …   Wikipédia en Français

  • neuraminidase — (= sialidase) Enzyme catalysing cleavage of neuraminic acid residues from oligosaccharide chains of glycoproteins and glycolipids. Since these residues are usually terminal, neuraminidases are generally exo enzymes, although an endoneuraminidase… …   Dictionary of molecular biology

  • Neuraminidase inhibitor — Neuraminidase inhibitors are a class of antiviral drugs targeted at the influenza virus, which work by blocking the function of the viral neuraminidase protein, thus preventing the virus from reproducing by budding from the host cell. Oseltamivir …   Wikipedia

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  • Neuraminidase-Inhibitor — Neuraminidase Hemmer bzw. Hemmstoffe der Neuraminidase sind Medikamente, die jenes Oberflächenprotein hemmen, das die Antigenität verschiedener Bakterien und Viren mitbestimmt. Das Influenzavirus bindet über virales Hämagglutinin an die… …   Deutsch Wikipedia

  • Neuraminidase-Inhibitoren — Neuraminidase Hemmer bzw. Hemmstoffe der Neuraminidase sind Medikamente, die jenes Oberflächenprotein hemmen, das die Antigenität verschiedener Bakterien und Viren mitbestimmt. Das Influenzavirus bindet über virales Hämagglutinin an die… …   Deutsch Wikipedia

  • Neuraminidase-Hemmer — Neuraminidase Hemmer,   Hemmstoffe der Neuraminidasen, die insbesondere zur Behandlung der Virusgrippe (Influenza) eingesetzt werden. Die Neuraminidasen sind Enzyme, die v. a. in pathogenen Bakterien und Viren vorkommen. Sie können Neuraminsäure… …   Universal-Lexikon

  • Neuraminidase-β-Galaktosidase-Mangel — Klassifikation nach ICD 10 E77.8 Sonstige Störungen des Glykoproteinstoffwechsels …   Deutsch Wikipedia

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