nitrosourea


nitrosourea
Alkylating agent used in the treatment of many neoplasms; an example is BCNU [N,N′-bis(2-chloroethyl)-N-n.; carmustine].

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ni·tro·so·urea -yu̇-'rē-ə n any of a group of lipid-soluble drugs that function as alkylating agents, have the ability to enter the central nervous system, and are effective in the treatment of some brain tumors and meningeal leukemias

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ni·tro·so·urea (ni-tro″so-uґre-ə) any of several chemically related antineoplastic agents including carmustine, lomustine, semustine, and the antibiotic streptozocin. Carmustine, lomustine, and semustine are closely related chemically, are highly lipid-soluble, cross the blood-brain barrier, and are used against brain tumors; they act by alkylation, carbamoylation, and inhibition of DNA repair; they are not cross-resistant with other alkylating agents and are highly effective against resting (G0) cells; the major side effect is dose-limiting bone marrow suppression. Streptozocin differs from the others in that it is not cross-resistant with them, is not myelosuppressive, and does not act by carbamoylation.

Medical dictionary. 2011.

Look at other dictionaries:

  • Nitrosourea — IUPAC name …   Wikipedia

  • nitrosourea — /nuy troh soh yoo ree euh/, n. Pharm. any of various lipid soluble, synthetic or naturally occurring alkylating agents that can cross the blood brain barrier: used in the treatment of certain brain cancers. [NITROSO + UREA] * * * …   Universalium

  • nitrosourea — noun The nitroso derivative of urea NH CONH N=O, or any of its derivatives, many of which are pharmaceuticals …   Wiktionary

  • nitrosourea — ni·tro·so·urea …   English syllables

  • nitrosourea — An anticancer drug that can cross the blood brain barrier. Carmustine and lomustine are nitrosoureas …   English dictionary of cancer terms

  • nitrosourea — ˌ noun Etymology: nitros + urea : any of a group of lipid soluble drugs that function as alkylating agents, have the ability to enter the central nervous system, and are effective in the treatment of some brain tumors and meningeal leukemias * *… …   Useful english dictionary

  • N-methyl-N-nitrosourea — N metil N nitrozokarbamidas statusas T sritis chemija formulė CH₃N(NO)CONH₂ atitikmenys: angl. N methyl N nitrosourea rus. N метил N нитрозомочевина …   Chemijos terminų aiškinamasis žodynas

  • sarcosinamide nitrosourea — A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called alkylating agents. Also called sarCNU …   English dictionary of cancer terms

  • ENU — For other uses, see ENU (disambiguation). ENU Systematic name 1 Ethyl 1 nitrosourea …   Wikipedia

  • N-Ethyl-N-nitrosoharnstoff — Strukturformel Allgemeines Name N Ethyl N nitrosoharnstoff Andere …   Deutsch Wikipedia


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