orotidylic acid

orotidylic acid
Orotidine 5′-monophosphate; an intermediate in the biosynthesis of the pyrimidine nucleosides (cytidine and uridine) that are found in nucleic acid s. SYN: orotidine 5′-monophosphate.
- o. decarboxylase an enzyme that catalyzes the conversion of OMP to UMP and CO2; a defect or inhibition of this enzyme will result in orotic aciduria and orotidinuria; this enzyme is a part of pyrimidine biosynthesis. Cf.:uridylic acid synthase. SYN: OMP decarboxylase.
- o. pyrophosphorylase SYN: orotate phosphoribosyltransferase.

* * *

orot·i·dyl·ic ac·id (ə-rot″ĭ-dilґik) phosphorylated orotidine, usually referring to orotidine 5′-phosphate (see orotidine).

Medical dictionary. 2011.

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  • Orotidine 5'-monophosphate — IUPAC name 3 [(2R,3R,4S,5R) 3,4 dihydroxy 5 ​(phosphonooxymethyl)oxolan 2 yl]​ 2,6 dioxo pyrimid …   Wikipedia

  • orotate — A salt or ester of orotic acid. o. phosphoribosyltransferase a phosphoribosyltransferase synthesizing orotidylate and pyrophosphate from o. and 5 phospho α d ribosyl 1 pyrophosphate; this enzyme is a part of pyrimidine …   Medical dictionary

  • orotidylate — A salt or ester of orotidylic acid. * * * orot·i·dyl·ate (ə rot″ĭ dilґāt) a dissociated form of orotidylic acid …   Medical dictionary

  • Orotidine — IUPAC name …   Wikipedia

  • Uridine monophosphate — Chembox new ImageFile=UMP chemical structure.png ImageSize= IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=58 97 9 PubChem=1172 SMILES=C1=CN(C(=O)NC1=O) C2C(C(C(O2)COP(=O)(O)O)O)O MeSHName=Uridine+monophosphate Section2= Chembox… …   Wikipedia

  • orotidine — Orotic acid 3 β d ribonucleoside; uridine 6 carboxylic acid; elevated in cases of orotidinuria. SYN: 1 ribosylorotate. o. 5′ monophosphate (OMP) SYN: orotidylic acid. * * * orot·i·dine (ə rotґĭ dēn) a nucleoside, orotic acid linked …   Medical dictionary

  • OMP — Abbreviation for oligo N methylmorpholinium propylene oxide; orotidylic acid; orotidylate; orotidine 5′ monophosphate. * * * olfactory marker protein; oligonucleoside methylphosphonate; ornithine monophosphate; orotidine 5´ monophos phatase;… …   Medical dictionary

  • OMP decarboxylase — SYN: orotidylic acid decarboxylase …   Medical dictionary

  • orotidinuria — Elevated levels of orotidine in the urine; has been observed in defects in and inhibition of orotidylic acid decarboxylase …   Medical dictionary

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