Hemoglobin S
The most common type of abnormal hemoglobin and the basis of sickle cell trait and sickle cell anemia. Hemoglobin S differs from normal adult hemoglobin (called hemoglobin A) only by a single amino acid substitution (a valine replacing a glutamine in the 6th position of the beta chain of globin). Recognition of this tiny change in the hemoglobin molecule marked the opening of molecular medicine.

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hemoglobin S n an abnormal hemoglobin occurring in the red blood cells in sickle-cell anemia and sickle-cell trait and differing from hemoglobin A in having a valine residue substituted for the glutamic-acid residue in position 6 of two of the four polypeptide chains making up the hemoglobin molecule

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the most common abnormal hemoglobin, having valine substituted for glutamic acid at position 6 of the β chain; the homozygous state results in sickle cell anemia, and the asymptomatic heterozygous state is called sickle cell trait.

Medical dictionary. 2011.

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  • hemoglobin F — hemoglobin F. См. гемоглобин F. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemoglobin — hemoglobin. См. гемоглобин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemoglobin C — hemoglobin C. См. гемоглобин С. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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