piperazine

Its former use in gout was based upon its property of dissolving uric acid in vitro, but it is ineffective in increasing uric acid excretion; its compounds are now used as anthelmintics in oxyuriasis and ascariasis. SYN: diethylenediamine.

- p. adipate a veterinary anthelmintic and filaricide.

- p. calcium edetate an anthelmintic.

- p. citrate a vermifuge for pinworms and roundworms.

- p. estrone sulfate a purified preparation of natural estrone sulfate; the p. acts as a buffer to increase the stability of estrone sulfate.

- p. tartrate an anthelmintic useful in the treatment of nematode infestation.

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pi·per·a·zine pī-'per-ə-.zēn n a crystalline heterocyclic base C₄H₁₀N₂ or C₄H₁₀N₂·6H₂O used esp. as an anthelmintic

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n.

a drug used to treat infestations by roundworms and threadworms. It is administered by mouth; side-effects do not usually occur, but continued treatment at high doses may cause nausea, vomiting, headache, tingling sensations, and rashes. Trade name: Pripsen.

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pi·per·a·zine (pi-perґə-zēn) [USP] an anthelmintic effective against the parasites Ascaris lumbricoides and Enterobius vermicularis; it causes a flaccid paralysis of the worm musculature by altering cell membrane permeability and causing hyperpolarization of the membrane. Called also diethylenediamine and piperazidine.