proinsulin


proinsulin
A single-chain precursor of insulin.

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pro·in·su·lin (')prō-'in(t)-s(ə-)lən n a single-chain pancreatic polypeptide precursor of insulin that gives rise to the double chain of insulin by loss of the middle part of the molecule

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n.
a substance produced in the pancreas from which the hormone insulin is derived.

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pro·in·su·lin (pro-inґsə-lin) a precursor of insulin, with a molecular weight of 8,000 to 10,000; it has minimal hormonal activity and is converted to insulin by removal of the connecting C peptide, leaving the two (A and B)-chain, active insulin molecule.

Medical dictionary. 2011.

Look at other dictionaries:

  • Proinsulin — is the prohormone precursor to insulin made in the beta cell of the islets of Langerhans. It is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where …   Wikipedia

  • proinsulin — [prō in′sə lin] n. a polypeptide molecule formed in the islets of Langerhans: hydrolysis of its peptide bonds yields insulin and a biochemically inactive peptide …   English World dictionary

  • Proinsulin — Schematische Darstellung der Prozessierung vom Präproinsulin über das Proinsulin zum Insulin. Proinsulin ist ein Prohormon und der Präkursor des Peptidhormons Insulin. Insulin wird als Präproinsulin in den β Zellen der Langerhans Inseln des… …   Deutsch Wikipedia

  • proinsulin — (ˈ)prōˌ noun Etymology: pro (I) + insulin : a single chain pancreatic polypeptide precursor of insulin that gives rise to the double chain of insulin by loss of the middle part of the molecule * * * proinsulin pro 2 1 …   Useful english dictionary

  • proinsulin — noun Date: 1916 a single chain pancreatic polypeptide precursor of insulin that gives rise to the double chain of insulin by cleavage and loss of the middle part of the molecule …   New Collegiate Dictionary

  • proinsulin — /proh in seuh lin, ins yeuh /, n. Biochem. the prohormone of insulin, converted into insulin by enzymatic removal of part of the molecule. [1915 20; PRO 1 + INSULIN] * * * …   Universalium

  • proinsulin — noun A polypeptide that is the prohormone precursor of insulin …   Wiktionary

  • Proinsulin — Pro|in|su|lin [↑ pro ] ↑ Insulin …   Universal-Lexikon

  • Proinsulin — Pro̱|insulin [↑pro... u. ↑Insulin] s; s, e: Vorstufe des Insulins …   Das Wörterbuch medizinischer Fachausdrücke

  • proinsulin — pro·insulin …   English syllables


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