saccharopine

saccharopine
A derivative of α-ketoglutarate and l-lysine that is an intermediate in l-lysine catabolism; elevated in cases of saccharopinuria.
- s. dehydrogenase two enzymes that are used in the pathway of l-lysine catabolism; the first isoform catalyzes the reversible conversion of l-lysine, α-ketoglutarate, and NADH to s. and NAD+; the other isoform reversibly catalyzes to conversion of s. and NAD+ to l-glutamate, NADH, and l-α-aminoadipate δ-semialdehyde. A deficiency of one of these isoforms is associated with familial hyperlysinemia and saccharopinuria.

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sac·cha·ro·pine (sakґə-ro-pēn″) an intermediate in the metabolism of lysine, formed by condensation of lysine and α-ketoglutarate; it accumulates abnormally in some disorders of lysine degradation.

Medical dictionary. 2011.

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  • saccharopine dehydrogenase (NAD+ L-glutamate-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NAD+, L glu·ta·mate form·ing) (sakґə ro pēn″ de hiґdro jən ās glooґtə māt formґing) [EC 1.5.1.9] official nomenclature for saccharopine dehydrogenase …   Medical dictionary

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