secretase

secretase
A term used to describe a proteinase that acts on amyloid precursor protein to produce peptides that do not contain the entire amyloid β protein (a major constituent of the plaques found in Alzheimer disease), are soluble, and do not precipitate to produce amyloid.

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se·cre·tase si-'krē-.tās n any of several transmembrane proteases that are capable of cleaving amyloid precursor protein and include two forms that function in the generation of beta-amyloid

Medical dictionary. 2011.

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  • secretase — noun a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer s) • Hypernyms: ↑enzyme …   Useful english dictionary

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  • Amyloid precursor protein — (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formationPriller C, Bauer T, Mitteregger G,… …   Wikipedia

  • Alzheimer's disease clinical research — As of August 2010 there were more than 800 clinical trials under way to understand and treat Alzheimer s disease. 149 of these studies were human phase three trials, the last step before U.S. Food and Drug Administration approval and marketing.… …   Wikipedia

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