tetrahydrofolic acid


tetrahydrofolic acid
The active coenzyme form of folic acid; participates in one-carbon metabolism. SYN: coenzyme F.

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tet·ra·hy·dro·fo·lic acid -.fō-lik- n a metabolically active reduced form C19H23N7O6 of folic acid that acts as a coenzyme in the transfer of groups (as a methyl group) containing a single carbon atom in metabolic synthesis (as of purines)

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(THF) tet·ra·hy·dro·fo·lic ac·id (THF) (tet″rə-hi″dro-foґlik) a form of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions. Tetrahydrofolic acid and its derivatives are required for the metabolism of several amino acids, the formation of creatine and choline, the methylation of RNA molecules, the synthesis of purines, and the synthesis of deoxythymidine monophosphate. Called also tetrahydropteroylglutamic acid.

Medical dictionary. 2011.

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