tetrodotoxin

tetrodotoxin
A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and certain newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. T. blocks voltage-gated Na+ channels in excitable tissues.

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te·tro·do·tox·in te-.trōd-ə-'täk-sən n a neurotoxin C11H17N3O8 that is found esp. in pufferfishes and that blocks nerve conduction by suppressing permeability of the nerve fiber to sodium ions

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n.
puffer-fish toxin, one of the most powerful known nerve toxins with a mortality of about 50%. There is no known antidote.

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tet·ro·do·tox·in (tetґro-do-tok″sin) a pure, crystalline, highly lethal neurotoxin present in puffer fish of the order Tetraodontidae and in newts of the genus Taricha (in which it is called tarichatoxin). Ingestion of improperly cooked flesh may result in tetrodotoxism within minutes. Called also tetraodontoxin.

Medical dictionary. 2011.

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  • tetrodotoxin — [te΄trə dō täk′sin] n. [< ModL Tetrodon, a genus of fishes (short for tetraodon < tetra ,TETRA + Gr odōn,TOOTH) + TOXIN] an extremely poisonous neurotoxin, C11H17N3O8, found in the puffer fishes and a genus ( Taricha) of newts, that blocks… …   English World dictionary

  • Tetrodotoxin — Chembox new ImageFile=Tetrodotoxin 2D skeletal.png ImageSize= ImageFile2=Tetrodotoxin 3D balls.png IUPACName=Octahydro 12 (hydroxymethyl) 2 imino 5,9:7,10a dimethano 10aH [1,3] dioxocino [6,5 d] pyrimidine 4,7,10,11,12 pentol… …   Wikipedia

  • Tetrodotoxin — Strukturformel Allgemeines Name Tetrodotoxin Summenformel …   Deutsch Wikipedia

  • tetrodotoxin — blowfish low fish n. 1. a fish eaten as a delicacy, especially in Japan. It is highly dangerous because of a potent nerve poison (tetrodotoxin) in its ovaries and liver. Chefs require special training to learn how to remove the poisonous parts,… …   The Collaborative International Dictionary of English

  • tetrodotoxin — Puffer Puff er, n. 1. One who puffs; one who praises with noisy or extravagant commendation. [1913 Webster] 2. One who is employed by the owner or seller of goods sold at suction to bid up the price; a by bidder. Bouvier. [1913 Webster] 3. (Zo[… …   The Collaborative International Dictionary of English

  • tetrodotoxin — Toxin Tox in, Toxine Tox ine, n. [Gr. toxiko n. See {Toxic}. ] A poisonous product formed by an organism, such as a pathogenic bacterium, a plant or an animal, usually having a high molecular weight, often a protein or a polysaccharide, but… …   The Collaborative International Dictionary of English

  • Tetrodotoxin — Te|t|ro|do|to|xin [nlat. Tetraodontidae = Kugelfische (griech. odoús, Gen.: odóntos = Zahn); ↑ Toxin] von Bakterien in Fischen, Mollusken, Amphibien etc. produziertes äußerst giftiges tetracycl. Alkaloid, das über die Nahrungskette eingeschleppt… …   Universal-Lexikon

  • tetrodotoxin — noun Etymology: International Scientific Vocabulary tetrodo (from New Latin Tetrodon, genus of tropical marine fishes) + toxin Date: 1911 a neurotoxin C11H17N3O8 found especially in puffer fish that blocks nerve conduction by suppressing… …   New Collegiate Dictionary

  • tetrodotoxin — the poison found in tetrodotoxic fishes; also called spheroidine, fugu toxin, or puffer poison (anhydrotetrodotoxin 4 epitetrodotoxin or tetrodonic acid). The empirical molecular formula is (C11 H17 N3 O8 HBr), a complex molecule. It is among the …   Dictionary of ichthyology

  • tetrodotoxin — A potent neurotoxin (319 D) from the Japanese puffer fish. It binds to the sodium channel, blocking the passage of action potentials. Its activity closely resembles that of saxitoxin …   Dictionary of molecular biology

  • tetrodotoxin — /te troh deuh tok sin/, n. Pharm. a neurotoxin, C11H17N3O3, occurring in a species of puffer fish: ingestion of the toxin is usually rapidly fatal due to heart failure or asphyxiation; used experimentally to block impulse conduction potential in… …   Universalium

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