Annexin V

Annexin V
Annexin V is the cause of a syndrome called the antiphospholipid antibody syndrome with abnormal blood clotting. The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids. Annexin V normally forms a shield around certain phospholipid molecules that blocks their entry into coagulation (clotting) reactions. In the antiphospholipid antibody syndrome, the formation of this shield is disrupted by the abnormal antibodies. Without the shield, there is an increased quantity of phospholipid molecules on cell membranes, speeding up coagulation reactions and causing the abnormal blood clotting characteristic of the antiphospholipid antibody syndrome.

Medical dictionary. 2011.

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  • Annexin A1 — (or Lipocortin I) is a human protein encoded by the ANXA1 gene. PBB Summary section title = summary text = Annexin I belongs to a family of Ca(2+) dependent phospholipid binding proteins that have a molecular weight of approximately 35,000 to… …   Wikipedia

  • Annexin A2 — is a pleiotropic protein, meaning that its function is dependent on place and time in the body. PBB Summary section title = summary text = This gene encodes a member of the annexin family. Members of this calcium dependent phospholipid binding… …   Wikipedia

  • Annexin A3 — Annexin A3, also known as ANXA3, is a human gene.cite web | title = Entrez Gene: ANXA3 annexin A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=306| accessdate = ] PBB Summary section title = summary text …   Wikipedia

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  • Annexin A5 affinity assay — Annexin A5 is a protein that binds in a calcium dependent manner to phosphatidylserine containing membrane surfaces. Cell surface expression of phosphatidylserine during cell deathApoptosis is a form of programmed cell death which is used by the… …   Wikipedia

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