uroporphyrinogen

uroporphyrinogen
- u. decarboxylase an enzyme that participates in heme biosynthesis; it catalyzes the decarboxylation of uroporphyrin III to produce coproporphyrinogen III; it also acts on uroporphyrin I; a deficiency of this enzyme will result in either porphyria cutanea tarda or hepatoerythropoietic porphyria.
- u. III cosynthase an enzyme in heme biosynthesis that participates in the formation of u. III; a deficiency of this protein results in congenital erythropoietic porphyria.

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uro·por·phy·rin·ogen .yu̇r-ō-.pȯr-fə-'rin-ə-jən n any of several porphyrins that can be converted to uroporphyrins or to a precursor of coproporphyrins

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uro·por·phy·rin·o·gen (u″ro-por″fə-rinґə-jən) a porphyrinogen (q.v.) in which each pyrrole ring has one acetate side chain and one propionate side chain; it is formed by condensation of four molecules of porphobilinogen. Four isomers are possible but only two exist naturally, types I and III; the latter is a functional intermediate in heme biosynthesis while the former is produced in an abortive side reaction.

Medical dictionary. 2011.

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  • Uroporphyrinogen — Uroporphyrinogens are tetrapyrroles with four propionic acid groups and four acetic acid groups.There are four forms, which vary based upon the arrangements of the groups ( P ) and ( A ): * In the I variety, clockwise, the order repeats four… …   Wikipedia

  • Uroporphyrinogen I — Chembox new ImageFile=Uroporphyrinogen I.png ImageSize=200px IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=1867 62 5 PubChem=440775 SMILES= Section2= Chembox Properties Formula=C40H44N4O16 MolarMass=836.795 Appearance= Density=… …   Wikipedia

  • Uroporphyrinogen III decarboxylase — Uroporphyrinogen decarboxylase, also known as UROD, is a human gene.cite web | title = Entrez Gene: UROD uroporphyrinogen decarboxylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7389| accessdate = ]… …   Wikipedia

  • Uroporphyrinogen-III-Synthase — Vorhandene Strukturdaten …   Deutsch Wikipedia

  • Uroporphyrinogen-Decarboxylase — Oberflächenmodell im Komplex mit Coproporphyrinogen nach PDB  …   Deutsch Wikipedia

  • Uroporphyrinogen III — Chembox new ImageFile=Uroporphyrinogen III skeletal.svg ImageSize= IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=1976 85 8 PubChem=1179 SMILES= MeSHName=Uroporphyrinogen+III Section2= Chembox Properties Formula=C40H44N4O16… …   Wikipedia

  • Uroporphyrinogen III synthase — protein Name = uroporphyrinogen III synthase caption = width = HGNCid = 12592 Symbol = UROS AltSymbols = EntrezGene = 7390 OMIM = 606938 RefSeq = NM 000375 UniProt = P10746 PDB = ECnumber = 4.2.1.75 Chromosome = 10 Arm = q Band = 25.2 26.3… …   Wikipedia

  • uroporphyrinogen-III synthase — uro·por·phy·rin·o·gen III syn·thase (u″ro por″fə rinґə jən sinґthās) [EC 4.2.1.75] an enzyme of the lyase class that acts concertedly with hydroxymethylbilane synthase to convert porphobilinogen to uroporphyrinogen …   Medical dictionary

  • Uroporphyrinogen decarboxylase deficiency — Lack of the enzyme uroporphyrinogen decarboxylase (UROD) which is the basic cause of porphyria cutanea tarda (PCT), the late skin form of porphyria. PCT is a genetic photosensitive (light sensitive) skin disease with onset in adult life with a… …   Medical dictionary

  • uroporphyrinogen III cosynthase — uro·por·phy·rin·o·gen III co·syn·thase (u″ro por″fə rinґə jən ko sinґthās) uroporphyrinogen III synthase …   Medical dictionary

  • uroporphyrinogen decarboxylase — uro·por·phy·rin·o·gen de·car·boxy·lase (u″ro por″fə rinґə jən de kahr bokґsə lās) [EC 4.1.1.37] an enzyme of the lyase class that catalyzes the decarboxylation of uroporphyrinogen III to coproporphyrinogen III …   Medical dictionary

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