vitronectin


vitronectin
A plasma glycoprotein involved in inflammatory and repair reactions at sites of tissue damage.

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vit·ro·nec·tin .vi-trō-'nek-tən n a glycoprotein of blood plasma that promotes cell adhesion and migration and is similar to fibronectin

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vit·ro·nec·tin (vit″ro-nekґtin) a multifunctional adhesive glycoprotein occurring in serum and various tissues and having binding sites for integrins, collagen, heparin, complement components and perforin. Its functions include regulation of the coagulation, fibrinolytic, and complement cascades, and it plays a role in hemostasis, wound healing, tissue remodeling, and cancer. It binds plasminogen activator inhibitor (PAI-1); mediates the inflammatory and repair reactions occurring at sites of tissue injury; and promotes adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as an inhibitor of complement activation, binding the membrane attack complex and preventing its insertion into the membrane.

Medical dictionary. 2011.

Look at other dictionaries:

  • Vitronectin — is an abundant glycoprotein found in blood plasma and the extracellular matrix. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy. Structure Vitronectin is a 75 kDa glycoprotein, consisting of 459 amino acid… …   Wikipedia

  • vitronectin — vitronectin. См. витронектин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • vitronectin — Serum protein (70 kD) also known as serum spreading factor from its activity in promoting adhesion and spreading of tissue cells in culture. Contains the cell binding sequence Arg Gly Asp (RGD) first found in fibronectin …   Dictionary of molecular biology

  • vitronectin — noun A protein of the pexin family, an abundant glycoprotein that promotes cell adhesion and spreading, inhibits the membrane damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors …   Wiktionary

  • витронектин — vitronectin – витронектин. Полифункциональный гликопротеин, компонент крови и внеклеточного матрикса <extracellular matrix>; взаимодействует с гликозаминогликанами, коллагеном, плазминогеном, рецептором урокиназы; стабилизирует ингибирующую …   Молекулярная биология и генетика. Толковый словарь.

  • VNR — vitronectin receptor …   Medical dictionary

  • VNRA — vitronectin receptor alpha …   Medical dictionary

  • VNR — • vitronectin receptor …   Dictionary of medical acronyms & abbreviations

  • VNRA — • vitronectin receptor alpha …   Dictionary of medical acronyms & abbreviations

  • ITGAV — Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) Rendering of 1JV2 …   Wikipedia