- Melanoma thickness
- A method for determining the prognosis (outlook) with melanoma. The thickness of a melanoma is related to the 5-year survival rate after surgical removal of the tumor. Also called Breslow thickness. Named for the physician Alexander Breslow who in 1975 observed that as the thickness of the tumor increases, the chance of survival goes down. For example, a thickness of the melanoma of less than 0.76 millimeters is associated with a 5-year survival of 97% of patients whereas a tumor thickness of more than 8.0 millimeters is associated with 5-year survival of 32%. The Breslow thickness has come into wider use than an older system, the Clark level of invasion, a method devised by the pathologist Wallace Clark for measuring the depth of penetration of a melanoma into the skin according to anatomic layer (the epidermis, dermis, and the subcutis) of deepest tumor penetration.
Medical dictionary. 2011.
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thickness — 1. The measure of the depth of something, as opposed to its length or width. 2. A layer or stratum. Breslow t. maximal t. of a primary cutaneous melanoma measured in tissue sections from the top of the epid … Medical dictionary
Breslow thickness — A method for determining the prognosis with melanoma. The thickness of a melanoma is related to the 5 year survival rate after surgical removal of the tumor. Named for the physician Alexander Breslow who in 1975 observed that as the thickness of… … Medical dictionary
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Breslow thickness — the distance (in millimetres) between the surface and the deepest extent of a malignant melanoma. The measurement correlates with prognosis; tumours that are less than 0.76 mm thick have a good prognosis. [A. Breslow (1928–80), US pathologist] … The new mediacal dictionary
stage III melanoma — The tumor may be any thickness, with or without ulceration (formation of a break on the skin or surface of an organ), and (1) has spread to 1 or more lymph nodes; or (2) has spread into the nearby lymph system but not into nearby lymph nodes; or… … English dictionary of cancer terms