Anthracycline


Anthracycline
A member of a family of chemotherapy drugs that are also antibiotics. The anthracyclines act to prevent cell division by disrupting the structure of the DNA and terminate its function. They do so in two ways: (1) they intercalate into the base pairs in the DNA minor grooves; and (2) they cause free radical damage of the ribose in the DNA. The anthracyclines are frequently used in leukemia therapy. The anthracyclines include daunorubicin (Cerubidine), doxorubicin (Adriamycin, Rubex), epirubicin (Ellence, Pharmorubicin), and idarubicin (Idamycin).
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Anticancer agent consisting of 3 moieties: a pigmented aglycone, an amino sugar, and a lateral chain. Examples are doxorubicin, daunorubicin, and daunomycin.

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an·thra·cy·cline .an(t)-thrə-'sī-.klēn n any of a class of antineoplastic drugs (as doxorubicin) derived from an actinomycete of the genus Streptomyces (esp. S. peucetius)

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n.
any of 500 or so antibiotics synthesized or isolated from species of Streptomyces. doxorubicin is the most important member of this group of compounds, which have wide activity against tumours.

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an·thra·cy·cline (an″thrə-siґklēn) any of a class of antineoplastic antibiotics, including daunorubicin and doxorubicin, produced by Streptomyces peucetius or S. coeruleorubidus and having a four-ring system to which a daunosamine molecule is attached by glycoside linkage (see illustration). Although the precise mechanism of action is unknown, anthracyclines can damage DNA by intercalation, metal ion chelation, and the generation of free radicals and can inhibit enzyme activity critical to DNA function. The use of these drugs is limited by dose-related cardiotoxicity.

Anthracycline. For daunorubicin, R1 = CH3; for doxorubicin, R1 = CHOH.


Medical dictionary. 2011.

Look at other dictionaries:

  • Anthracycline — Image stack align=right image size=200 image1 c Daunorubicin, the prototypical anthracycline image2 c Doxorubicin image3 c Epirubicin Epirubicin image4 c IdarubicinAnthracyclines (or anthracycline antibiotics) are a class of drugs used in cancer… …   Wikipedia

  • Anthracycline — Daunorubicine, l anthracycline prototypique Doxorubicine …   Wikipédia en Français

  • Anthracycline — Strukturformeln von Doxorubicin und Epirubicin. Anthracycline sind aus Streptomyces Arten isolierte Antibiotika, die in der Chemotherapie als Zytostatika gegen verschiedene Krebsarten eingesetzt werden. Anthracycline wirken unter anderem, indem… …   Deutsch Wikipedia

  • anthracycline — noun any of a class of antibiotic, chemotherapeutic agents used to treat cancer …   Wiktionary

  • anthracycline — an·thra·cy·cline …   English syllables

  • anthracycline — n. any of 500 or so antibiotics synthesized or isolated from species of Streptomyces. Doxorubicin is the most important member of this group of compounds, which have wide activity against tumours (see cytotoxic drug) …   The new mediacal dictionary

  • anthracycline — A type of antibiotic that comes from the fungus Streptococcus peucetius. Anthracyclines are used as treatments for cancer. Daunorubicin, doxorubicin, and epirubicin are anthracyclines …   English dictionary of cancer terms

  • anthracycline — ˌan(t)thrəˈsīˌklēn, klə̇n noun ( s) Etymology: anthr + cycline (as in tetracycline) : any of a class of antineoplastic drugs (as doxorubicin) derived from an actinomycete of the genus Streptomyces (especially S. peucetius) …   Useful english dictionary

  • Антрациклин (Anthracycline) — любой из 500 антибиотиков, синтезируемый или выделяемый из бактерий семейства Streptomyces. Доксорубицин является основным представителем данной группы соединений, так как обладает широким спектром действия против различных опухолей. Источник:… …   Медицинские термины

  • Anthracyclines — Anthracycline Les anthracyclines sont une famille de médicaments anticancéreux d origine naturelle, isolés comme les antibiotiques de micro organismes (actinobactéries du genre streptomyces), a été découverte en 1963 presque simultanément par une …   Wikipédia en Français

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