Monoamine oxidase inhibitor
One of a potent class of medications used to treat depression. Abbreviated MAOI.

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monoamine oxidase inhibitor n any of various antidepressant drugs which increase the concentration of monoamines in the brain by inhibiting the action of monoamine oxidase

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(MAOI) any of a group of antidepressant drugs that have the ability to block the oxidative deamination of monoamines. It is thought that by inhibiting monoamine oxidase activity the inhibitors increase the level of catecholamines in the central nervous system, which would have been otherwise neutralized by the enzyme, and that these increased concentrations are responsible for their antidepressant effects. They are also used in the prophylaxis of migraine.

Medical dictionary. 2011.

Look at other dictionaries:

  • monoamine-oxidase inhibitor — noun One of a class of drugs that allow the build up of serotonin in the brain, used to treat severe depression (abbrev MAOI) • • • Main Entry: ↑monoamine …   Useful english dictionary

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • monoamine oxidase inhibitor — noun Medicine any of a group of antidepressant drugs which inhibit the activity of monoamine oxidase (so allowing accumulation of serotonin and noradrenaline in the brain) …   English new terms dictionary

  • monoamine oxidase inhibitor — noun any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate • Syn: ↑MAOI • Hypernyms: ↑antidepressant, ↑antidepressant drug • Hyponyms: ↑iproclozide, ↑isocarboxazid,… …   Useful english dictionary

  • monoamine oxidase inhibitor — Pharm. any of various substances, as isocarboxazid and phenelzine, that block enzymatic breakdown of certain monoamine neurotransmitters: used to treat severe depression. Abbr.: MAOI Also called MAO inhibitor. [1960 65] * * * …   Universalium

  • monoamine oxidase inhibitor — mon′oamine′ ox′idase inhib itor n. pha any of various substances that block enzymatic breakdown of certain monoamine neurotransmitters and that are used to treat depression Abbr.: MAOI • Etymology: 1960–65 …   From formal English to slang

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  • monoamine oxidase — SYN: amine oxidase (flavin containing). * * * monoamine oxidase n an enzyme that deaminates monoamines oxidatively and that functions in the nervous system by breaking down monoamine neurotransmitters * * * (MAO) an enzyme that catalyses the… …   Medical dictionary

  • monoamine oxidase — MAO an enzyme that catalyses the oxidation of a large variety of monoamines, including adrenaline, noradrenaline, and serotonin. Monoamine oxidase is found in most tissues, particularly the liver and nervous system. Drugs that act as inhibitors… …   The new mediacal dictionary

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