Myelofibrosis

Myelofibrosis
Fibrosis (spontaneous scarring) of the bone marrow. This can be associated with a variety of diseases, primarily myeloproliferative (pre-leukemic) disorders. Sometimes used interchangeably with agnogenic myeloid metaplasia. Myelofibrosis is characterized by significant anemia and an enlarged spleen. Acute myelofibrosis is a distinct disorder characterized by acute inadequate blood cell production (pancytopenia), marrow fibrosis, but no enlargement of the spleen or liver.
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Fibrosis of the bone marrow, especially generalized, associated with myeloid metaplasia of the spleen and other organs, leukoerythroblastic anemia, and thrombocytopenia, although the bone marrow often contains many megakaryocytes. SYN: myelosclerosis, osteomyelofibrotic syndrome.

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my·e·lo·fi·bro·sis .mī-ə-lō-fī-'brō-səs n, pl -bro·ses -.sēz an anemic condition in which bone marrow becomes fibrotic and the liver and spleen usu. exhibit a development of blood-cell precursors
my·e·lo·fi·brot·ic -'brät-ik adj

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n.
a chronic but progressive disease characterized by fibrosis of the bone marrow, which leads to anaemia and the presence of immature red and white blood cells in the circulation. Other features include enlargement of the spleen and the presence of blood-forming (myeloid) tissue in abnormal sites, such as the spleen and liver (extramedullary haemopoiesis). Its cause is unknown.

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my·elo·fi·bro·sis (mi″ə-lo-fi-broґsis) replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder such as agnogenic myeloid metaplasia or secondary to another unrelated condition. Called also myelosclerosis.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Myelofibrosis — Classification and external resources ICD 10 C94.5, D47.1 ICD 9 …   Wikipedia

  • myelofibrosis — n. (Med.) Fibrosis of the bone marrow. [WordNet 1.5] …   The Collaborative International Dictionary of English

  • myelofibrosis with myeloid metaplasia — myelofibrosis associated with extramedullary hematopoiesis; generally restricted to agnogenic myeloid metaplasia (with which it is often used synonymously) and myeloid metaplasia secondary to polycythemia vera or essential thrombocythemia …   Medical dictionary

  • myelofibrosis — noun Etymology: New Latin Date: 1947 an anemic condition in which bone marrow becomes fibrotic and the liver and spleen usually exhibit a development of blood cell precursors • myelofibrotic adjective …   New Collegiate Dictionary

  • myelofibrosis — /muy euh loh fuy broh sis/, n. Pathol. the replacement of bone marrow by fibrous tissue, characteristic of leukemia and certain other diseases. [1945 50; MYELO + FIBROSIS] * * * …   Universalium

  • myelofibrosis — noun A myeloproliferative disorder of the bone marrow, in which the marrow undergoes fibrosis …   Wiktionary

  • myelofibrosis — my·elo·fibrosis …   English syllables

  • myelofibrosis — n. a chronic but progressive disease characterized by fibrosis of the bone marrow, which leads to anaemia and the presence of immature red and white blood cells in the circulation. Other features include enlargement of the spleen and the presence …   The new mediacal dictionary

  • myelofibrosis — my•e•lo•fi•bro•sis [[t]ˌmaɪ ə loʊ faɪˈbroʊ sɪs[/t]] n. pat the replacement of bone marrow by fibrous tissue, characteristic of leukemia and certain other diseases • Etymology: 1945–50 …   From formal English to slang

  • myelofibrosis — A disorder in which the bone marrow is replaced by fibrous tissue …   English dictionary of cancer terms

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