Apolipoprotein E
: A gene that codes for a protein in lipoproteins (complexes of fat + protein) that are normal constituents of blood plasma — namely, chylomicrons, HDL (high density lipoprotein), LDL (low density lipoprotein), and VLDL (very low density lipoprotein). The abbreviation for apolipoprotein E is ApoE. Studies of families in which Alzheimer disease tends to develop at later ages have shown that the disease is unusually frequent in persons with a particular variant form of ApoE termed ApoE4 present in only a minority of the general population. However, family studies suggest that the ApoE gene locus is neither necessary nor sufficient to cause Alzheimer disease and may simply modify the preclinical progression, and therefore the age of onset, in people otherwise predisposed to develop Alzheimer disease. The ApoE gene is now known to be on chromosome 19.

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an apolipoprotein, apo E, that occurs in all classes of lipoproteins; it may be involved in the conversion of very-low-density to intermediate-density lipoprotein and its clearance from the circulation.

Medical dictionary. 2011.

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  • Apolipoprotein E — (APOE) is an apoprotein found in the chylomicron that binds to a specific receptor on liver cells and peripheral cells. It is essential for the normal catabolism of triglyceride rich lipoprotein constituents.cite web | title = Entrez Gene: APOE… …   Wikipedia

  • Apolipoprotein E — Bändermodell der Aminosäuren 1 191 des Apolipoprotein E4 nach PDB  …   Deutsch Wikipedia

  • Apolipoprotein A1 — Apolipoprotein A I, also known as APOA1, is a human gene.The protein encoded by this gene is an apolipoprotein. It is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to …   Wikipedia

  • Apolipoprotein C3 — Apolipoprotein C III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in… …   Wikipedia

  • Apolipoprotein D — Apolipoprotein D, also known as APOD, is a human gene.cite web | title = Entrez Gene: APOD apolipoprotein D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=347| accessdate = ] PBB Summary section title =… …   Wikipedia

  • Apolipoprotein — Als Apolipoproteine (Apo von griechisch άπό: Ab , Weg ) bezeichnet man den Proteinanteil der Lipoproteine (u. a. Chylomikronen, VLDL, LDL, IDL, HDL), der die wasserunlöslichen Lipide im Blut transportiert. Die Apolipoproteine bilden zusammen mit… …   Deutsch Wikipedia

  • Apolipoprotein B — (APOB) is the primary apolipoprotein of low density lipoproteins (LDL or bad cholesterol ), which is responsible for carrying cholesterol to tissues. While it is unclear exactly what functional role APOB plays in LDL, it is the primary… …   Wikipedia

  • Apolipoprotein A1 — Zwei ApoA1 Moleküle (lila Bänder) im Komplex mit Cholesterin (orange Kalotten) und Phospholip …   Deutsch Wikipedia

  • Apolipoprotein — Apolipoproteins are proteins that bind to fats (lipids). They form lipoproteins, which transport dietary fats through the bloodstream. Dietary fats are digested in the intestine and carried to the liver. Fats are also synthesized in the liver… …   Wikipedia

  • apolipoprotein — The protein component of any lipoprotein complexes that is a normal constituent of plasma chylomicrons, HDL, LDL, and VLDL in humans. a. A I an a. found in HDL and chylomicrons. It is an activator of LCAT and a ligand for the HDL receptor. A… …   Medical dictionary

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