Aromatase


Aromatase
An enzyme (actually an enzyme complex) involved in the production of estrogen that acts by catalyzing the conversion of testosterone (an androgen) to estradiol (an estrogen). Aromatase is located in estrogen-producing cells in the adrenal glands, ovaries, placenta, testicles, adipose (fat) tissue, and brain. The growth of some breast cancers is promoted by estrogens. For example, the drug letrozole (brand name: Femara) is an antiestrogen sometimes used to treat such estrogen-dependent tumors. The drug acts by inhibiting the enzyme aromatase which lowers the level of the estrogen, estradiol.

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aro·ma·tase ə-'rō-mə-.tās, -.tāz n an enzyme or complex of enzymes that promotes the conversion of an androgen (as testosterone) into estrogens (as estradiol)

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aro·ma·tase (ə-roґmə-tās) an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol, proceeding via three successive hydroxylations, loss of a carbon atom, and rearrangement.

Medical dictionary. 2011.

Look at other dictionaries:

  • Aromatase — Bändermodell nach PDB  …   Deutsch Wikipedia

  • aromatase — aromatase. См. ароматаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Aromatase — Cytochrome P450, family 19, subfamily A, polypeptide 1 Crystallographic structure of the human aromatase cytochrome P450 (rainbow colored cartoon, N terminus = blue, C terminus = red) in complex with the cofactor protoporphyrin IX (top) and the… …   Wikipedia

  • Aromatase — L’aromatase est une enzyme responsable de la biosynthèse des œstrogènes. Les œstrogènes peuvent être la cause de cancers ou d autres maladies, les inhibiteurs de l aromatase sont fréquemment utilisés pour traiter ces pathologies. Aromatase… …   Wikipédia en Français

  • aromatase — noun Etymology: aromatic + ase Date: 1984 an enzyme or complex of enzymes that promotes the conversion of an androgen into estrogen …   New Collegiate Dictionary

  • aromatase — Microsomal enzyme complex that converts testosterone to oestradiol …   Dictionary of molecular biology

  • aromatase — noun An enzyme that selectively increases the aromaticity of androgen hormones …   Wiktionary

  • Aromatase — A|ro|ma|ta|se [↑ aromatisch (2) u. ↑ ase], die; , n; Syn.: Östrogen Synthetase: ein Enzym, das ↑ Androgene wie Testosteron in ↑ Östrogene wie Östradiol umwandelt (↑ Aromatisierung, 2) …   Universal-Lexikon

  • Aromatase — Aromata̲se [zu ↑aromatisch u. ↑...ase] w; , n: Enzym, das die Umwandlung von Androgen in Östrogen vermittelt …   Das Wörterbuch medizinischer Fachausdrücke

  • aromatase — aro·ma·tase …   English syllables


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