Silencing, gene


Silencing, gene
A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent. The process of gene silencing is important for the differentiation of many different types of cells.

Medical dictionary. 2011.

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  • silencing — Loss of gene expression either through an alteration in the DNA sequence of a structural gene, or its regulatory region; or because of interactions between its transcript and other mRNAs present in the cell (see: antisense RNA) …   Glossary of Biotechnology