- Abbreviation for selective serotonin reuptake inhibitors, commonly prescribed drugs for treating depression. SSRIs affect the chemicals that nerves in the brain use to send messages to one another. These chemical messengers, called neurotransmitters, are released by one nerve and taken up by other nerves. Neurotransmitters that are not taken up by other nerves are taken up by the same nerves that released them. This process is termed "reuptake." SSRIs work by inhibiting the reuptake of serotonin, an action which allows more serotonin to be available to be taken up by other nerves. The most commonly prescribed SSRIs as of 1999 were paroxetine (brandname Paxil), fluoxetine (brandname Prozac) and sertraline (brandname Zoloft). All three of these SSRIs appear equally efficacious, according to a 1999 study.
The rate of patients switching from one class of drugs to another did not differ among the drug classes studied and there was no significant difference in the proportion of patients who switched from an SSRI to another SSRI (or another type of antidepressant), regardless of whether paroxetine (Paxil), fluoxetine (Prozac) or sertraline (Zoloft) was the initial therapy. These three SSRIs therefore are "equivalent in their effectiveness" but they "...are not interchangeable, because patients who discontinue one SSRI for lack of tolerability or response can generally be treated effectively with another." (Reference: J Clin Psychiatry 1999;60:574-579.)
* * *selective serotonin reuptake inhibitor
* * *SSRI .es-(.)es-(.)är-'ī n any of a class of antidepressants (as fluoxetine or sertraline) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic nerve cell endings called also selective serotonin reuptake inhibitor
* * *any one of a group of antidepressant drugs that exert their action by blocking the reabsorption of the neurotransmitter serotonin by the nerve endings in the brain. Their effect is to prolong the action of serotonin in the brain. The group includes citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. Side-effects include agitation and nausea.
* * *selective serotonin reuptake inhibitor.
Medical dictionary. 2011.
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SSRI — (ĕs ĕs är īʹ) n. A class of drugs, such as fluoxetine or sertraline, that inhibit the uptake of serotonin by neurons of the central nervous system and are primarily used in the treatment of depression and obsessive compulsive disorder. … … Universalium
SSRI — (Selektive) Serotonin Wiederaufnahmehemmer (SSRI = Selective Serotonin Reuptake Inhibitor) sind Antidepressiva, die am Serotonin Transporter ihre Wirkung entfalten und dabei die Serotonin Konzentration in der Gewebeflüssigkeit des Gehirns erhöhen … Deutsch Wikipedia
SSRI — Inhibiteur sélectif de la recapture de la sérotonine Les inhibiteurs sélectifs de la recapture de la sérotonine (ISRS ; SSRI en anglais) sont une classe d antidépresseurs. Ils opèrent dans le cerveau afin d augmenter le taux de sérotonine (5 … Wikipédia en Français
SSRI — noun an antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain • Syn: ↑selective serotonin reuptake inhibitor • Hypernyms: ↑antidepressant, ↑antidepressant drug •… … Useful english dictionary
SSRI — noun Date: 1991 any of a class of antidepressants (as fluoxetine) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic neuron endings called also selective serotonin reuptake inhibitor … New Collegiate Dictionary
SSRI — Selective Serotonin Reuptake Inhibitor (Medical » Physiology) * Silver Standard Resources, Inc. (Business » NASDAQ Symbols) * Serotonin Selective Reuptake Inhibitors (Medical) * Selective Seratonin Reuptake Inhibitor (Medical) * Selective… … Abbreviations dictionary
SSRI — abbreviation Medicine selective serotonin reuptake inhibitor, any of a group of antidepressant drugs (including Prozac) which inhibit the uptake of serotonin in the brain … English new terms dictionary
SSRI — abbr. Social Systems Research Institute … Dictionary of abbreviations
SSRI — selective serotonin reuptake inhibitor any one of a group of antidepressant drugs that exert their action by blocking the reabsorption of the neurotransmitter serotonin by the nerve endings in the brain. Their effect is to prolong the action of… … The new mediacal dictionary
SSRI — pha Selective Serotonin Reuptake Inhibitor: any of several drugs that inhibit the reabsorption of serotonin by nerve cells, leading to more serotonin activity in the brain: used chiefly as an antidepressant • Etymology: 1985–90 … From formal English to slang