Arthus reaction


Arthus reaction
Ar·thus reaction 'är-thəs-, ȧr-'tues- n a reaction that follows injection of an antigen into an animal in which hypersensitivity has been previously established and that involves infiltrations, edema, sterile abscesses, and in severe cases gangrene called also Arthus phenomenon
Ar·thus ȧr-tues Nicolas Maurice (1862-1945)
French bacteriologist and physiologist. Arthus was primarily concerned with venoms and antivenins and with coagulability and anticoagulants. In 1890 he published an article on coagulation that demonstrated for the first time the essential role of calcium in blood coagulation. In 1903, in an article reporting a study involving repeated injections of horse serum into rabbits, he reported discovery of the phenomenon of local anaphylaxis, a phenomenon that has since become identified with his name.

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the development of an inflammatory lesion, with induration, erythema, edema, hemorrhage, and necrosis, a few hours after intradermal injection of antigen into a previously sensitized animal producing precipitating antibody; it is classed as a type III hypersensitivity reaction in the Gell and Coombs classification of immune responses. The lesion results from the precipitation of antigen-antibody complexes, which causes complement activation and the release of complement fragments that are chemotactic for neutrophils; large numbers of neutrophils infiltrate the site and cause tissue destruction by release of lysosomal enzymes. Called also Arthus phenomenon.

Medical dictionary. 2011.

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  • Arthus reaction — Infobox Disease Name = Arthus reaction Caption = DiseasesDB = 33220 ICD10 = ICD10|T|78|4|t|66 ICD9 = ICD9|995.21 ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D001183 In immunology, the Arthus reaction is a type of local… …   Wikipedia

  • Arthus' reaction — /ahr tooh siz/, Immunol. a severe, local immune reaction to the injection of an antigen in a sensitized host. Also called Arthus phenomenon. [after Nicolas Maurice Arthus (1862 1945), French physiologist, who discovered it in 1903] * * * …   Universalium

  • Arthus' reaction — /ahr tooh siz/, Immunol. a severe, local immune reaction to the injection of an antigen in a sensitized host. Also called Arthus phenomenon. [after Nicolas Maurice Arthus (1862 1945), French physiologist, who discovered it in 1903] …   Useful english dictionary

  • Arthus reaction — A localized inflammation due to injection of antigen into an animal that has a high level of circulating antibody against that antigen. A haemorrhagic reaction with oedema occurs due to the destruction of small blood vessels by thrombi. It may… …   Dictionary of molecular biology

  • Arthus reaction — inflammatory response to the introduction of a foreign substance into the blood vessels or tissues of a body (that already has antibodies against those antigens) …   English contemporary dictionary

  • Arthus reaction (phenomenon) — Ar·thus reaction (phenomenon) (ahr tūsґ) [Nicolas Maurice Arthus, French physiologist, 1862–1945] see under reaction …   Medical dictionary

  • reverse passive Arthus reaction — the reaction produced when precipitating antibody is inoculated into a skin site in an experimental animal, followed in 30 minutes to 2 hours by inoculation of the homologous antigen, either intravenously or intracutaneously at the same site.… …   Medical dictionary

  • passive cutaneous Arthus reaction — a variation of the Arthus reaction in which a nonimmune host is inoculated with large quantities of precipitating antibody intravenously, followed by local cutaneous inoculation of antigen …   Medical dictionary

  • Arthus реакция — * Arthus рэакцыя * Arthus reaction комплементзависимая реакция гиперчувствительности, которая проявляется в виде реакции антигена с антителами (осаждение). При этом образуются микропреципитаты (осажденные микрочастицы), которые повреждают клетки …   Генетика. Энциклопедический словарь

  • Arthus-type reaction — any pathologic process involving the same mechanism as the Arthus reaction, i.e., deposition of immune complexes and complement activation, as in immune complex disease …   Medical dictionary