Syndrome, Werner

Syndrome, Werner
A premature aging disease that begins in adolescence or early in adulthood and results in apparent old age by 30-40 years of age. The characteristic features of Werner syndrome include short stature, premature graying and balding, wizened face, beaked nose, cataracts, scleroderma-like skin changes (especially in the extremities), subcutaneous calcification (deposits of calcium beneath the skin), premature arteriosclerosis, muscular atrophy and tendencies to diabetes mellitus and to tumors (especially, osteosarcoma and meningioma). The disorder is inherited as an autosomal recessive trait. Cells from patients with Werner syndrome have a shorter lifespan in cell culture than do normal cells. The gene for Werner syndrome, symbolized WRN, is on chromosome 8 (in the region of bands 8p12-p11.2. It is a RECQL2 gene which encodes what is termed a RecQ DNA helicase. Bloom syndrome, which has features quite different from those of Werner syndrome, is caused by defects in another human RecQ-like helicase, RECQL3. Werner syndrome has been much studied as a genetic model of aging. It is named for the German physician Otto Werner (1879-1936). In his doctoral dissertation in 1904, Werner described 4 sisters with cataracts and scleroderma-like skin. The name "Werner's syndrome" was first used in 1934 by two Americans, BS Oppenheimer and Kugel VH, who rediscovered Werner's dissertation. Werner syndrome has nothing whatsoever to do with Werner-His disease which is a louse-borne illness first recognized in the trenches of World War I and so named trench fever.

Medical dictionary. 2011.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Werner's syndrome — Wer·ner s syndrome ver nərz n a rare hereditary disorder characterized by premature aging with associated abnormalities (as dwarfism, cataracts, osteoporosis, and hypogonadism) called also Werner syndrome Werner Otto (1879 1936) German physician …   Medical dictionary

  • Syndrome de werner — Autre nom Progeria de l adulte Pangérie Référence MIM …   Wikipédia en Français

  • Syndrome de Werner — Référence MIM 277700 Transmission Récessive Chromosome 8p12 p11.2 Gène WRN Empreinte parentale Non …   Wikipédia en Français

  • Syndrome du burnout — Syndrome d épuisement professionnel Pour les articles homonymes, voir burnout et épuisement. Syndrome d épuisement professionnel CIM 10 : Z73.0 …   Wikipédia en Français

  • Syndrôme d'épuisement professionnel — Syndrome d épuisement professionnel Pour les articles homonymes, voir burnout et épuisement. Syndrome d épuisement professionnel CIM 10 : Z73.0 …   Wikipédia en Français

  • Werner (name) — Werner is a name of Germanic origins. It is common both as a given name and a surname. There are alternate spellings, such as the Scandinavian, Verner .The oldest known usage of the name was in the Habsburg family. * Werner I, Bishop of… …   Wikipedia

  • Werner syndrome — Werner syndrome. См. прогерия взрослых. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Werner Bärtschi-Rochaix — (* 9. Januar 1911 in Bern; † 1994) war ein Schweizer Neurologe. Inhaltsverzeichnis 1 Leben 2 Bärtschi Rochaix Syndrom 3 Werke …   Deutsch Wikipedia

  • Werner Catel — (1894 1981), Professor of Neurology and Psychiatry at the University of Leipzig, was one of three doctors considered an expert on the programme of euthanasia for children and participated in the Action T4 euthanasia program for the Nazis, the… …   Wikipedia

  • Werner syndrome — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 14096 ICD10 = ICD9 = ICD9|259.8 ICDO = OMIM = 277700 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshName = Werner+Syndrome MeshNumber = C16.320.925 Werner Syndrome (WRN) is a very rare,… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”