Teratogen


Teratogen
Any agent that can disturb the development of an embryo or fetus. Teratogens may cause a birth defect in the child. Or a teratogen may halt the pregnancy outright. The classes of teratogens include radiation, maternal infections, chemicals, and drugs. Drugs known to be capable of acting as teratogens include, but are by no means limited to, ACE inhibitors like benazepril (brand name: Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril sodium (Monopril), lisinopril (Zestril, Prinivil), lisinopril and hydrochlorothiazide (Zestoretic, Prinzide), quinapril (Accupril), and ramipril (Altace); the acne medication isotretinoin (Accutane, Retin-A); alcohol, whether ingested chronically or in binges; androgens (male hormones); the antibiotics tetracycline (Achromycin), doxycycline (Vibramycin), and streptomycin; blood-thinners, such as warfarin (Coumadin); seizure medications, including phenytoin (Dilantin), valproic acid (Depakene, Depakote, Valprotate), trimethadione (Tridione), paramethadione (Paradione), and carbamazepine (Tegretol); the anti- depressant/anti-manic drug lithium (Eskalith, Lithotab); antimetabolite/anticancer drugs methotrexate (Rheumatrex) and aminopterin; the antirheumatic agent and chelator penicillamine (Ciprimene, Depen); antithyroid drugs, such as thiouracil/propylthiouracil and carbimazole/methimazole; cocaine; DES (diethylstilbestrol), a hormone; and thalidomide (Thalomid). Obviously, alcohol and illegal or unnecessary drugs should never be used by women who are pregnant, or who plan to get pregnant. However, sometimes a medication necessary for health is also a teratogen: thyroid medication, blood thinners, and lithium are just a few examples. In these cases, female patients should work carefully with their doctors to determine if an alternative treatment is possible before and during pregnancy. In some cases the danger of birth defects is limited to a certain part of the pregnancy, and medication can be started again after that period has passed. Other medications can be safely restarted with the baby’s birth. Some medications also pass through breast milk, however, and if they cannot be avoided the mother may need to choose formula feeding instead.
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A drug or other agent that causes abnormal prenatal development. [terato- + G. -gen, producing]

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te·rato·gen tə-'rat-ə-jən n a teratogenic agent (as a drug or virus)

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n.
any substance, agent, or process that induces the formation of developmental abnormalities in a fetus. Known teratogens include such drugs as thalidomide and alcohol; such infections as German measles and cytomegalovirus; and also irradiation with X-rays and other ionizing radiation. Compare mutagen.
teratogenic adj.

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ter·a·to·gen (terґə-to-jən) any agent or factor that induces or increases the incidence of abnormal prenatal development.

Medical dictionary. 2011.

Look at other dictionaries:

  • teratogen — TERATOGÉN, Ă, teratogeni, e, adj. (med.) Care produce malformaţii, anomalii etc. – Din fr. tératogène. Trimis de LauraGellner, 13.09.2007. Sursa: DEX 98  teratogén adj. m., pl. teratogéni; f. sg. tera …   Dicționar Român

  • teratogen — teratogen. См. тератоген. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • teratogen — (n.) 1959, from comb. form of Gk. teras (gen. teratos) marvel, monster + GEN (Cf. gen) …   Etymology dictionary

  • teratogen — teratògen prid. <odr. ī> DEFINICIJA pat. koji uzrokuje nakaznost ploda [teratogeni virusi; teratogeni lijekovi; teratogena zračenja; teratogene tvari] ETIMOLOGIJA terato + gen …   Hrvatski jezični portal

  • teratogen — [ter′ə tə jən] n. [ TERATO + GEN] an agent, as a chemical or disease, that causes malformation of a fetus teratogenic [ter′ə tōjen′ik] adj …   English World dictionary

  • teratogen — Missbildungen erzeugend * * * te|ra|to|gen 〈Adj.〉 Missbildungen hervorrufend ● teratogene Stoffe, Mittel [<grch. teras, Gen. terators „Zeichen, Vorzeichen, Schreckbild“ + gennan „erzeugen“] * * * Te|ra|to|gen [↑ Tera u. ↑ gen], das; s, e:… …   Universal-Lexikon

  • Teratogen — Fruchtschädigend am Menschen Fruchtschädigend an Tier und Pflanze Giftig (T) Umweltgefährlich (N) …   Deutsch Wikipedia

  • teratogen — teratogenas statusas T sritis augalininkystė apibrėžtis Išsigimimą sukeliantis veiksnys. atitikmenys: angl. teratogen rus. тератоген …   Žemės ūkio augalų selekcijos ir sėklininkystės terminų žodynas

  • teratogen — noun Date: 1959 a teratogenic agent …   New Collegiate Dictionary

  • teratogen — n. [Gr. teras, monster; genes, producing] Any substance that causes or increases the incidence of congenital abnormalities in a population …   Dictionary of invertebrate zoology