- Therapy, gene
- Insertion of normal DNA directly into cells to correct a genetic defect. The treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease. In studies of gene therapy for cancer, for example, researchers are trying to bolster the body's natural capacity to combat cancer and make the tumor more sensitive to other kinds of therapy. Gene therapy, still in its early stages, holds great promise for the treatment of many diseases. The first gene therapy was done successfully in humans in 1990 by W. French Anderson, R. Michael Blaese and Kenneth W. Culver who infused genetically engineered blood cells to repair an immune deficiency disorder: adenosine deaminase (ADA) deficiency. In late October of 1999 the U.S. moved to require the disclosure of the results of gene therapy. The move by the Recombinant DNA Advisory Committee came 6 weeks after the death of an 18-year-old Arizona man, Jesse Gelsinger, who was apparently the first person to die as a result of gene therapy. Researchers at the University of Pennsylvania, where Mr. Gelsinger received gene therapy, were prompt to report his death and talked of it publicly. Although there was no evidence that any other patients had died as a result of receiving gene therapy, the committee (which reports to the director of the National Institutes of Health) was concerned that some scientists and companies had not always been so forthcoming with information about side effects experienced by gene therapy patients.
Medical dictionary. 2011.
Look at other dictionaries:
Gene therapy — using an Adenovirus vector. A new gene is inserted into an adenovirull. If the treatment is successful, the new gene will make a functional protein. Gene therapy is the insertion, alteration, or removal of genes within an individual s cells and… … Wikipedia
Therapy, human gene — Insertion of normal DNA directly into cells to correct a genetic defect. The treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease. In studies … Medical dictionary
gene therapy — noun : the insertion of usually genetically altered genes into cells especially to replace defective genes in the treatment of genetic disorders or to provide a specialized disease fighting function (as the destruction of tumor cells) • gene… … Useful english dictionary
therapy — /ther euh pee/, n., pl. therapies. 1. the treatment of disease or disorders, as by some remedial, rehabilitating, or curative process: speech therapy. 2. a curative power or quality. 3. psychotherapy. 4. any act, hobby, task, program, etc., that… … Universalium
gene — /jeen/, n. the basic physical unit of heredity; a linear sequence of nucleotides along a segment of DNA that provides the coded instructions for synthesis of RNA, which, when translated into protein, leads to the expression of hereditary… … Universalium
Gene — /jeen/, n. a male given name, form of Eugene. * * * I Unit of heredity that occupies a fixed position on a chromosome. Genes achieve their effects by directing protein synthesis. They are composed of DNA, except in some viruses that contain RNA… … Universalium
gene therapist — noun see gene therapy * * * gene therapist noun • • • Main Entry: ↑gene … Useful english dictionary
gene therapy — n the insertion of usu. genetically altered genes into cells esp. to replace defective genes in the treatment of genetic disorders or to provide a specialized disease fighting function (as the destruction of tumor cells) gene therapist n * * *… … Medical dictionary
Gene doping — is defined by the World Anti Doping Agency as the non therapeutic use of cells, genes, genetic elements, or of the modulation of gene expression, having the capacity to improve athletic performance . [http://www.wada… … Wikipedia
Gene synthesis — is the process of synthesizing an artificially designed gene into a physical DNA sequence.Gene synthesis was first demonstrated by Har Gobind Khorana in 1970 for a short artificial gene. Nowadays, commercial gene synthesis services are available… … Wikipedia