- hy·drox·y·lase hī-'dräk-sə-.lās, -.lāz n any of a group of enzymes that catalyze oxidation reactions in which one of the two atoms of molecular oxygen is incorporated into the substrate and the other is used to oxidize NADH or NADPH
* * *hy·drox·y·lase (hi-drokґsə-lās) a general term used to denote enzymes of the oxidoreductase class that catalyze the formation of a hydroxyl group on a substrate by incorporation of oxygen from O2 [EC 1.13, 1.14]. Most are monooxygenases incorporating one atom of oxygen; more rarely the term is applied to a dioxygenase hydroxylating two substrates.
Medical dictionary. 2011.