Y chromosome sex-determining region

Y chromosome sex-determining region
A region on the Y chromosome that determines the sex of the individual. This region goes by the symbol SRY (sex region Y). SRY is necessary and sufficient for male sex determination. It is the testis-determining factor. Mutations in SRY give rise to XY females with gonadal dysgenesis who appear to be normal females at birth, but at puberty do not develop secondary sexual characteristics (breasts, etc.), do not menstruate, and have streak (fibrous) gonads without eggs. There is a high incidence of neoplasia (gonadoblastoma and germinoma) in the streak gonads. Translocation (transfer) of the part of the Y chromosome containing SRY to the X chromosome results in XX males — individuals who have XX sex chromosomes but appear male. SRY resides in chromosome band Yp11.3 and encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA binding proteins.

Medical dictionary. 2011.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Chromosome 22 (human) — Chromosome 22 is one of the 23 pairs of chromosomes in human cells. Humans normally have two copies of Chromosome 22 in each cell. Chromosome 22 is the second smallest human chromosome, spanning about 49 million DNA base pairs and representing… …   Wikipedia

  • Chromosome, Y — The sex chromosome found together with an X chromosome in most normal males. Once thought to be a genetic wasteland, the Y now is known to contain at least 20 genes, some of them unique to the Y including the male determining gene and male… …   Medical dictionary

  • Sex-Chromatin — Der Zellkern eines menschlichen, weiblichen Fibroblasten wurde mit dem blau fluoreszierenden …   Deutsch Wikipedia

  • Sex determination and differentiation (human) — Human sex determination refers to the processes by which an individual becomes either a male or female during development.The Jost ParadigmUnder typical circumstances, the sex of an individual will be determined and expressed through the… …   Wikipedia

  • Y chromosome — Human Y chromatid The Y chromosome is one of the two sex determining chromosomes in most mammals, including humans. In mammals, it contains the gene SRY, which triggers testis development if present. The human Y chromosome is composed of about 60 …   Wikipedia

  • XY sex-determination system — Drosophila sex chromosomes The XY sex determination system is the sex determination system found in humans, most other mammals, some insects (Drosophila) and some plants (Ginkgo). In this system, females have two of the same kind of sex… …   Wikipedia

  • Y chromosome — The sex chromosome found together with an X chromosome in most normal males. Once thought to be a genetic wasteland, the Y now is known to contain at least 20 genes, some of them unique to the Y including the male determining gene and male… …   Medical dictionary

  • Pseudoautosomale Region — Ausschnitt aus einer menschlichen Metaphase Spreitung. Eine Region in der pseudoautosomalen Region auf den kurzen Armen des X Chromosoms (links) und des Y Chromosoms (rechts oben) wurde mit Fluoreszenz in situ Hybridisierung nachgewiesen (grüne… …   Deutsch Wikipedia

  • Sex hormone-binding globulin — (SHBG) is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. Transport of sex hormonesThese sex hormones… …   Wikipedia

  • Chromosome — For a non technical introduction to the topic, see Introduction to genetics. Diagram of a replicated and condensed metaphase eukaryotic chromosome. (1) Chromatid – one of the two identical parts of the chromosome after S phase. (2)… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”