Y-linkage

The presence of a gene on the Y chromosome. Y-linkage is analogous to X-linkage (the presence of a gene on the X chromosome) in that it says a gene is on one of the sex chromosomes. It has often been said that little is known about Y-linkage. This is no longer true. As of the year 2000, a number of genes were known to be Y-linked including: {{}}ASMTY (which stands for acetylserotonin methyltransferase), TSPY (testis-specific protein), IL3RAY (interleukin-3 receptor), SRY (sex-determining region), TDF (testis determining factor), ZFY (zinc finger protein), PRKY (protein kinase, Y-linked), AMGL (amelogenin), CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome), ANT3Y (adenine nucleotide translocator-3 on the Y), AZF2 (azoospermia factor 2), BPY2 (basic protein on the Y chromosome), AZF1 (azoospermia factor 1), DAZ (deleted in azoospermia), RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1), RBM2 (RNA binding motif protein 2) and UTY (ubiquitously transcribed TPR gene on Y chromosome).

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The state of a genetic factor (gene) being borne on the Y chromosome. This idea is analogous with X-linkage, but since the Y chromosome does not fully take part in chiasma formation and recombination, it is not amenable to analysis by conventional linkage methods. Little is known about its content. There is a gene for the H-Y antigen, and indirect arguments suggest that there is a principle that determines the formation of the testis and masculinization of the fetus but its localization, though narrowing the limits, remains elusive.