Zollinger-Ellison syndrome


Zollinger-Ellison syndrome
A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach, and the upper portions of the small intestine (the duodenum and jejunum). Gastrinomas resulting in the Zollinger-Ellison syndrome are not limited to the pancreas but may also occur in the stomach, duodenum, spleen and lymph nodes. The treatment of the Zollinger-Ellison syndrome includes the use of H2 antagonists (for example cimetidine [brand name: Tagamet] and ranitidine [Zantac]) and the proton pump inhibitors (for example, lansoprazole [Prevacid] and omeprazole [Prilosec]). The H2 antagonists block the action of histamine on stomach cells, thus reducing stomach acid production. The proton pump inhibitors also block the production of acid by the stomach cells. Surgical removal of the tumor is curative in about 25% of cases. The syndrome is named for two American surgeons Robert M. Zollinger (1903-1992) and Edwin H. Ellison (1918-1970).

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Zol·ling·er-El·li·son syndrome 'zäl-iŋ-ər-'el-i-sən- n a syndrome consisting of fulminant intractable peptic ulcers, gastric hypersecretion and hyperacidity, and the occurrence of gastrinomas of the pancreatic cells of the islets of Langerhans
Zollinger Robert Milton (1903-1992)
American surgeon. Zollinger served for many years as professor and chief of surgical services at the medical school of Ohio State University. He was also editor in chief of the American Journal of Surgery.
Ellison Edwin Homer (1918-1970)
American surgeon. Ellison was a professor of surgery at Marquette University's medical school. His fields of research included blood volume studies in surgical patients, hormones of the pancreas, pathogenesis of ulcers, and nutrition in surgical patients.

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a rare disorder in which there is excessive secretion of gastric juice due to high levels of circulating gastrin, which is produced by a pancreatic tumour (see gastrinoma) or an enlarged pancreas. The high levels of stomach acid cause diarrhoea and peptic ulcers, which may be multiple, in unusual sites (e.g. jejunum), or which may quickly recur after vagotomy or partial gastrectomy. Treatment with an H2-receptor antagonist or proton-pump inhibitor, by removal of the tumour (if benign), or by total gastrectomy is usually effective.
R. M. Zollinger (1903-92) and E. H. Ellison (1918-70), US physicians

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(ZES) a triad comprising extreme gastric hyperacidity; peptic ulcers that are intractable and sometimes fulminating; and gastrinomas (gastrin-secreting islet cell tumors) that may appear outside the pancreas, such as in the duodenum. See also multiple endocrine neoplasia, type 1.

Medical dictionary. 2011.

Look at other dictionaries:

  • ZOLLINGER-ELLISON (SYNDROME DE) — ZOLLINGER ELLISON SYNDROME DE Le syndrome de Zollinger Ellison est une affection endocrinienne caractérisée par une hyperproduction de gastrine du fait d’une tumeur (plus souvent maligne que bénigne) ou d’une hyperplasie endocrine siégeant le… …   Encyclopédie Universelle

  • Zollinger-Ellison syndrome — Infobox Disease Name = PAGENAME Caption = Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger Ellison syndrome DiseasesDB = ICD10 = ICD10|E|16|4|e|15 ICD9 = ICD9|251.5 ICDO = OMIM = MedlinePlus = 000325… …   Wikipedia

  • Zollinger-Ellison syndrome — noun syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity • Hypernyms: ↑syndrome * * * ¦zäliŋər¦elə̇sən noun Usage: usually capitalized Z&E Etymology: after Robert M. Zollinger died 1992 and Edwin H.… …   Useful english dictionary

  • Zollinger-Ellison syndrome — /zol ing euhr el euh seuhn/, Pathol. a condition in which a gastrin secreting tumor of the pancreas or small intestine causes excessive secretion of gastric juice, leading to intractable peptic ulcers. [after Robert Milton Zollinger (born 1903)… …   Universalium

  • Zollinger-Ellison syndrome — a rare disorder in which there is excessive secretion of gastric juice due to high levels of circulating gastrin, which is produced by a pancreatic tumour (see gastrinoma) or an enlarged pancreas. The high levels of stomach acid cause diarrhoea… …   The new mediacal dictionary

  • Zollinger-Ellison syndrome — noun A disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid; often caused by a tumor (gastrinoma) of the duodenum or pancreas, and resulting in peptic ulcers …   Wiktionary

  • Zollinger-Ellison syndrome — A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine) …   English dictionary of cancer terms

  • Zollinger - Ellison syndrome — …   Useful english dictionary

  • Zollinger–Ellison syndrome — …   Useful english dictionary

  • Zollinger-Ellison-Syndrom — Klassifikation nach ICD 10 E16.4 Abnorme Gastrinsekretion Zollinger Ellison Syndrom …   Deutsch Wikipedia


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