therapeutic index

therapeutic index
therapeutic index n a measure of the relative desirability of a drug for the attaining of a particular medical end that is usu. expressed as the ratio of the largest dose producing no toxic symptoms to the smallest dose routinely producing cures

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the ratio of a dose of a therapeutic agent that produces damage to normal cells to the dose that is necessary to have a defined level of anticancer activity. It indicates the relative efficacy of a treatment against tumours.

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originally, the ratio of the maximum tolerated dose to the minimum curative dose; now defined, so as to account for variability of individual response, as the ratio of the median lethal dose (LD50) to the median effective dose (ED50). It is used in assessing the safety of a drug. Called also chemotherapeutic i.

Medical dictionary. 2011.

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  • Therapeutic index — The therapeutic index (also known as therapeutic ratio), is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxic effects. Quantitatively, it is the ratio given by the toxic dose… …   Wikipedia

  • therapeutic index — noun : a measure of the relative desirability of a drug for attaining a particular medical end that is usually expressed as the ratio of the largest dose producing no toxic symptoms to the smallest dose routinely producing cures * * * Pharm. the… …   Useful english dictionary

  • therapeutic index — Pharm. the ratio between the dosage of a drug that causes a lethal effect and the dosage that causes a therapeutic effect. Also called margin of safety. [1925 30] * * * …   Universalium

  • therapeutic index — the ratio of a dose of a therapeutic agent that produces damage to normal cells to the dose that is necessary to have a defined level of anticancer activity. It indicates the relative efficacy of a treatment against tumours …   The new mediacal dictionary

  • therapeutic index — ther′apeu′tic in′dex n. pha the ratio between the dosage of a drug that causes a lethal effect and the dosage that causes a therapeutic effect • Etymology: 1925–30 …   From formal English to slang

  • therapeutic index — noun Date: 1926 a measure of the relative desirability of a drug for the attaining of a particular medical end that is usually expressed as the ratio of the largest dose producing no toxic symptoms to the smallest dose routinely producing cures …   New Collegiate Dictionary

  • Therapeutic window — (or pharmaceutical window) is an index for estimation of drug dosage which can treat disease effectively while staying within the safety range. In other words, it is the dosage of a medication between the amount that gives an effect (effective… …   Wikipedia

  • therapeutic window — n 1) the range of dosage of a drug or of its concentration in a bodily system that provides safe effective therapy <the narrow therapeutic window...the effect may go from therapeutic to toxic with an increase of just 10 micrograms per… …   Medical dictionary

  • therapeutic — index curative, cure, medicinal, palliative (abating), remedial, salubrious, salutary Burton s Legal Th …   Law dictionary

  • Therapeutic effect — A therapeutic effect is a consequence of a medical treatment, of any kind, the results of which are judged to be desirable and beneficial. This is true whether the result was expected, unexpected, or even an unintended consequence of the… …   Wikipedia

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