tumor suppressor gene

tumor suppressor gene
tumor suppressor gene n any of a class of genes (as p53) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation called also anti-oncogene

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a gene whose function is to limit cell proliferation and loss of whose function leads to cell transformation and tumor growth; called also antioncogene.

Medical dictionary. 2011.

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  • tumor-suppressor gene — A gene that regulates cell growth. If such a gene becomes dysfunctional, and potentiating damage occurs to the cell, then uncontrolled growth and a cancer may result. See: p53 gene, oncogene …   Glossary of Biotechnology

  • tumor suppressor gene — noun Date: 1985 any of a class of genes (as p53) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation …   New Collegiate Dictionary

  • suppressor gene — noun a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene) • Syn: ↑suppressor, ↑suppresser, ↑suppresser gene • Hypernyms: ↑gene, ↑cistron, ↑factor • …   Useful english dictionary

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  • Gene therapy — using an Adenovirus vector. A new gene is inserted into an adenovirull. If the treatment is successful, the new gene will make a functional protein. Gene therapy is the insertion, alteration, or removal of genes within an individual s cells and… …   Wikipedia

  • suppressor — noun 1. someone who suppresses dictators are suppressors of free speech • Syn: ↑suppresser • Derivationally related forms: ↑suppress (for: ↑suppresser), ↑suppress …   Useful english dictionary

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