- The heterocyclic sulfonamide, 5-acetylamido-1,3,4-thiadiazole-2-sulfonamide, which inhibits the action of carbonic anhydrase in the kidney, increasing the urinary excretion of sodium, potassium, and bicarbonate, reducing excretion of ammonium, raising the pH of the urine, and lowering the pH of the blood; used in respiratory acidosis for diuresis and to stimulate respiratory drive, in glaucoma to reduce intraocular pressure, and in epilepsy. A. sodium has the same actions and uses as a., but is more soluble and thus more suitable for parenteral administration.
* * *ac·et·azol·amide .as-ət-ə-'zōl-ə-.mīd, -'zäl-, -məd n a diuretic drug C4H6N4O3S2 used esp. to treat glaucoma, control epileptic seizures, prevent or treat altitude sickness, and treat edema associated with congestive heart failure
* * *n.a carbonic anhydrase inhibitor used mainly in the treatment of glaucoma to reduce the pressure inside the eyeball and also as a preventative for epileptic seizures and altitude sickness. It is administered by mouth or injection; side-effects include drowsiness and numbness and tingling of the hands and feet. Trade name: Diamox.
* * *ac·et·a·zol·a·mide (as″et-ə-zolґə-mīd) [USP] a carbonic anhydrase inhibitor with a wide variety of uses, including adjunctive treatment of glaucoma and epilepsy, treatment of familial periodic paralysis, prophylaxis and treatment of acute mountain sickness, and as a urinary alkalizer in the prophylaxis and treatment of uric acid renal calculi; administered orally, intravenously, and intramuscularly.
Medical dictionary. 2011.