LHRH analogue


LHRH analogue
any one of a group of analogues of luteinizing hormone releasing hormone, which stimulates the release of luteinizing hormone (LH) from the pituitary gland. LHRH analogues are more powerful than the naturally occurring hormone, initially increasing the secretion of LH by the pituitary: this acts to block the hormone receptors and to inhibit the release of further LH. LHRH analogues, which are also known as GnRH analogues (see gonadotrophin-releasing hormone) or LHRH agonists, are effective in the treatment of endometriosis; administered by depot injection or nasal spray, they ensure ovarian suppression. They are also used to shrink fibroids and in the treatment of some types of infertility. Two LHRH analogues, goserelin (Zoladex) and leuprorelin (Prostap), are increasingly being used in the treatment of advanced prostate cancer. Both are given subcutaneously in depot form into the abdominal wall at one- or three-monthly intervals. After causing an initial rise in plasma testosterone for approximately ten days the level then falls to the same low level as that achieved by castration. Because the initial flare in testosterone may cause an acute enlargement of the cancer, anti-androgen are given at the same time. See also buserelin, gonadorelin.

Medical dictionary. 2011.

Look at other dictionaries:

  • LHRH analogue — see gonadorelin analogue …   The new mediacal dictionary

  • GnRH analogue, LHRH analogue — gonadorelin analogue …   The new mediacal dictionary

  • Аналог Лютеинизирующего Гормона (Lhrh Analogue) — один из аналогов рилизинг фактора лютеинизирующего гормона (lutcinizing hormone releasing hormone), который стимулирует высвобождение лютеинизирующего гормона гипофизом (см. также Гормон гонадотропина высвобождающий). Аналоги лютеинизирующего… …   Медицинские термины

  • analogue — SYN: analog. * * * an·a·logue or an·a·log an əl .ȯg, .äg n 1) something that is analogous or similar to something else 2) an organ similar in function to an organ of another animal or plant but different in structure and origin 3) usu analog a… …   Medical dictionary

  • gonadorelin analogue — GnRH analogue, LHRH analogue any one of a group of analogues of gonadotrophin releasing hormone (gonadorelin), which stimulates the release of luteinizing hormone (LH) and follicle stimulating hormone (gonadotrophins) from the pituitary gland.… …   The new mediacal dictionary

  • GnRH analogue — see gonadotrophin releasing hormone LHRH analogue …   Medical dictionary

  • АНАЛОГ ЛЮТЕИНИЗИРУЮЩЕГО ГОРМОНА — (LHRH analogue) один из аналогов рилизинг фактора лютеинизирующего гормона (lutcinizing hormone releasing hormone), который стимулирует высвобождение лютеинизирующего гормона гипофизом (см. также Гормон гонадотропина высвобождающий). Аналоги… …   Толковый словарь по медицине

  • goserelin — A synthetic decapeptide agonist analog of the LHRH (GnRH). It inhibits pituitary gonadotropin secretion and is used in the treatment of prostate cancer, breast …   Medical dictionary

  • gonadorelin — n. a synthetic analogue of gonadotrophin releasing hormone (see LHRH analogue), administered by intravenous injection to stimulate the production of pituitary gonadotrophins. It is used in the treatment of amenorrhoea and certain types of… …   Medical dictionary

  • Endometriosis — In endometriosis, cells that normally grow inside the uterus (womb), instead grow outside the uterus. Summary: Endometriosis is very common; the cause and why some women have endometriosis and many others do not has not been fully fathomed,… …   Medical dictionary


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