- acetylcholinesterase inhibitor
- any one of a class of drugs that block the action of acetylcholinesterase (see cholinesterase), an enzyme that quickly breaks down the neurotransmitter acetylcholine. This neurotransmitter is central to the functional interconnection between nerve cells in the outer layer (cortex) of the brain; the early impairment of cognitive function found in Alzheimer's disease is associated with a reduction in acetylcholine levels. By inhibiting acetylcholine breakdown, acetylcholinesterase inhibitors have been found helpful in slowing down the rate of cognitive decline in the early stages of the dementia; they do not halt the progress of the disease. The group includes donepezil (Aricept), galantamine (Reminyl), and rivastigmine (Exelon); these drugs are given by mouth.
Medical dictionary. 2011.
Look at other dictionaries:
Acetylcholinesterase inhibitor — Acetylcholine … Wikipedia
acetylcholinesterase inhibitor — any one of a class of drugs that block the action of acetylcholinesterase (see cholinesterase), an enzyme that quickly breaks down the neurotransmitter acetylcholine. This neurotransmitter is central to the functional interconnection between… … The new mediacal dictionary
Acetylcholinesterase — Acetylcholinesterase, also known as AChE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. It is mainly found at neuromuscular junctions and cholinergic… … Wikipedia
Enzyme inhibitor — Enzyme inhibitors are molecules that bind to enzymes and decrease their activity. Since blocking an enzyme s activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. They are also used as herbicides and… … Wikipedia
Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… … Wikipedia
Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… … Wikipedia
Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… … Wikipedia
COX-2 inhibitor — COX 2 selective inhibitor is a form of non steroidal anti inflammatory drug (NSAID) that directly targets COX 2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX 2 reduces the risk of peptic ulceration, and is the… … Wikipedia
Dihydropteroate synthase inhibitor — A dihydropteroate synthetase inhibitor is a drug that inhibits the action of dihydropteroate synthetase. Most are sulfonamides. Tetrahydrofolate synthesis pathway In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme … Wikipedia
Reverse-transcriptase inhibitor — Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors, and cancer. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce.… … Wikipedia